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An In Vitro and In Vivo Analysis of the Correlation between Susceptibility-Weighted Imaging Phase Values and R2* in Cirrhotic Livers (SWI Phase Images in Cirrhotic Livers)

Tao, Ran ; Zhang, Jiuquan ; Dai, Yongming ; You, Zhonglan ; Fan, Yi ; Cui, Jinguo ; Wang, Jian; Wang, Yi (Editor)

2012, Vol.7(9), p.e45477 [Tạp chí có phản biện]

E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0045477

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  • Nhan đề:
    An In Vitro and In Vivo Analysis of the Correlation between Susceptibility-Weighted Imaging Phase Values and R2* in Cirrhotic Livers (SWI Phase Images in Cirrhotic Livers)
  • Tác giả: Tao, Ran ; Zhang, Jiuquan ; Dai, Yongming ; You, Zhonglan ; Fan, Yi ; Cui, Jinguo ; Wang, Jian
  • Wang, Yi (Editor)
  • Chủ đề: Research Article ; Medicine ; Infectious Diseases ; Gastroenterology And Hepatology ; Radiology And Medical Imaging
  • Là 1 phần của: 2012, Vol.7(9), p.e45477
  • Mô tả: To establish a baseline of susceptibility-weighted imaging (SWI) phase value as a means of detecting iron abnormalities in cirrhotic liver and to analyze its relationship with R2*. ; Sixteen MnCl phantoms, thirty-seven healthy individuals and 87 cirrhotic patients were performed SWI and multi-echo T2*-weighted imaging, and the signal processing in NMR (SPIN) software was used to measure the radian on SWI phase images and the R2* on T2* maps. The mean minus two times standard deviation (SD) of Siemens Phase Unit (SPU) in healthy individuals was designated as a threshold to separate the regions of interest (ROIs) into high- and low-iron areas in healthy participants and cirrhotic patients. The SWI phase values of high-iron areas were calculated. The R2* values was measured in the same ROI in both healthy participants and patients. ; SWI phase values correlated linearly with R2* values in cases of MnCl concentrations lower than 2.3 mM in vitro ( = −0.996, <0.001). The mean value and SD of 37 healthy participants were 2003 and 15 (SPU), respectively. A threshold of 1973 SPU (−0.115 radians) was determined. The SWI phase value and R2* values had a negative correlation in the cirrhotic patients (−0.742, <0.001). However, no similar relationship was found in the healthy individuals (0.096,  = 0.576). Both SWI phase values and R2* values were found to have significant correlations with serum ferritin concentrations in 42 patients with blood samples ( = −0.512, 0.001 and 0.641, <0.001, respectively). ; SWI phase values had significant correlations with R2* after the establishment of a baseline on the phase image. SWI phase images may be used for non-invasive quantitative measurement of mild and moderate iron deposition in hepatic cirrhosis in vivo.
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0045477

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