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An In Vitro and In Vivo Analysis of the Correlation between Susceptibility-Weighted Imaging Phase Values and R2* in Cirrhotic Livers (SWI Phase Images in Cirrhotic Livers)

Tao, Ran ; Zhang, Jiuquan ; Dai, Yongming ; You, Zhonglan ; Fan, Yi ; Cui, Jinguo ; Wang, Jian; Wang, Yi (Editor)

2012, Vol.7(9), p.e45477 [Tạp chí có phản biện]

E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0045477

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  • Nhan đề:
    An In Vitro and In Vivo Analysis of the Correlation between Susceptibility-Weighted Imaging Phase Values and R2* in Cirrhotic Livers (SWI Phase Images in Cirrhotic Livers)
  • Tác giả: Tao, Ran ; Zhang, Jiuquan ; Dai, Yongming ; You, Zhonglan ; Fan, Yi ; Cui, Jinguo ; Wang, Jian
  • Wang, Yi (Editor)
  • Chủ đề: Research Article ; Medicine ; Infectious Diseases ; Gastroenterology And Hepatology ; Radiology And Medical Imaging
  • Là 1 phần của: 2012, Vol.7(9), p.e45477
  • Mô tả: To establish a baseline of susceptibility-weighted imaging (SWI) phase value as a means of detecting iron abnormalities in cirrhotic liver and to analyze its relationship with R2*. ; Sixteen MnCl phantoms, thirty-seven healthy individuals and 87 cirrhotic patients were performed SWI and multi-echo T2*-weighted imaging, and the signal processing in NMR (SPIN) software was used to measure the radian on SWI phase images and the R2* on T2* maps. The mean minus two times standard deviation (SD) of Siemens Phase Unit (SPU) in healthy individuals was designated as a threshold to separate the regions of interest (ROIs) into high- and low-iron areas in healthy participants and cirrhotic patients. The SWI phase values of high-iron areas were calculated. The R2* values was measured in the same ROI in both healthy participants and patients. ; SWI phase values correlated linearly with R2* values in cases of MnCl concentrations lower than 2.3 mM in vitro ( = −0.996, <0.001). The mean value and SD of 37 healthy participants were 2003 and 15 (SPU), respectively. A threshold of 1973 SPU (−0.115 radians) was determined. The SWI phase value and R2* values had a negative correlation in the cirrhotic patients (−0.742, <0.001). However, no similar relationship was found in the healthy individuals (0.096,  = 0.576). Both SWI phase values and R2* values were found to have significant correlations with serum ferritin concentrations in 42 patients with blood samples ( = −0.512, 0.001 and 0.641, <0.001, respectively). ; SWI phase values had significant correlations with R2* after the establishment of a baseline on the phase image. SWI phase images may be used for non-invasive quantitative measurement of mild and moderate iron deposition in hepatic cirrhosis in vivo.
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0045477
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     ©2016 Library and Information Center, Vietnam National University, Hanoi. All Right Reserved.
     ©2016 Library and Information Center, Vietnam National University, Hanoi. All Right Reserved.
  Nhà C1T, Đại học Quốc gia Hà Nội
144 Xuân Thủy, Cầu Giấy, Hà Nội
  (024) 3754 6545    lic@vnu.edu.vn

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