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Structural insights into RNA duplexes with multiple 2΄-5΄-linkages

Shen, Fusheng ; Luo, Zhipu ; Liu, Hehua ; Wang, Rui ; Zhang, Shenglong ; Gan, Jianhua ; Sheng, Jia

Nucleic acids research, 07 April 2017, Vol.45(6), pp.3537-3546 [Tạp chí có phản biện]

E-ISSN: 1362-4962 ; PMID: 28034958 Version:1 ; DOI: 10.1093/nar/gkw1307

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  • Nhan đề:
    Structural insights into RNA duplexes with multiple 2΄-5΄-linkages
  • Tác giả: Shen, Fusheng ; Luo, Zhipu ; Liu, Hehua ; Wang, Rui ; Zhang, Shenglong ; Gan, Jianhua ; Sheng, Jia
  • Chủ đề: RNA, Double-Stranded -- Chemistry
  • Là 1 phần của: Nucleic acids research, 07 April 2017, Vol.45(6), pp.3537-3546
  • Mô tả: 2΄-5΄-linked RNAs play important roles in many biological systems. In addition, the mixture of 2΄-5΄ and 3΄-5΄ phosphodiester bonds have emerged as a plausible structural element in prebiotic RNAs. Toward our mechanistic studies of RNA folding and structures with heterogeneous backbones, we recently reported two crystal structures of a decamer RNA duplex containing two and six 2΄-5΄-linkages, showing how RNA duplexes adjust the structures to accommodate these non-canonical linkages (Proc. Natl. Acad. Sci. USA, 2014, 111, 3050-3055). Herein, we present two additional high-resolution crystal structures of the same RNA duplex containing four and eight 2΄-5΄-linkages at different positions, providing new insights into the effects of these modifications and a dynamic view of RNA structure changes with increased numbers of 2΄-5΄-linkages in the same duplex. Our results show that the local structural perturbations caused by 2΄-5΄ linkages can be distributed to nearly all the nucleotides with big...
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1362-4962 ; PMID: 28034958 Version:1 ; DOI: 10.1093/nar/gkw1307

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