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The activity of the wheat MAP kinase phosphatase 1 is regulated by manganese and by calmodulin

Ghorbel, Mouna ; Zaidi, Ikram ; Robe, Eugénie ; Ranty, Benoit ; Mazars, Christian ; Galaud, Jean-Philippe ; Hanin, Moez

Biochimie, January 2015, Vol.108, pp.13-19 [Tạp chí có phản biện]

ISSN: 0300-9084 ; E-ISSN: 1638-6183 ; DOI: 10.1016/j.biochi.2014.10.021

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  • Nhan đề:
    The activity of the wheat MAP kinase phosphatase 1 is regulated by manganese and by calmodulin
  • Tác giả: Ghorbel, Mouna ; Zaidi, Ikram ; Robe, Eugénie ; Ranty, Benoit ; Mazars, Christian ; Galaud, Jean-Philippe ; Hanin, Moez
  • Chủ đề: Calmodulin ; Ca2+ ; Enzyme Regulation ; MAP Kinase Phosphatase ; Mn2+ ; Engineering ; Chemistry ; Anatomy & Physiology
  • Là 1 phần của: Biochimie, January 2015, Vol.108, pp.13-19
  • Mô tả: MAPK phosphatases (MKPs) are negative regulators of MAPKs in eukaryotes and play key roles in the regulation of different cellular processes. However in plants, little is known about the regulation of these Dual Specific Phosphatases (DSPs) by Ca and calmodulin (CaM). Here, we showed that the wheat MKP (TMKP1) harboring a calmodulin (CaM) binding domain, binds to CaM in a Ca -dependent manner. In addition, TMKP1 exhibited a phosphatase activity that is specifically enhanced by Mn and to a lesser extent by Mg , but without any synergistic effect between the two bivalent cations. Most interestingly, CaM/Ca complex inhibits the catalytic activity of TMKP1 in a CaM-dose dependent manner. However, in the presence of Mn this activity is enhanced by CaM/Ca complex. These dual regulatory effects seem to be mediated via interaction...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0300-9084 ; E-ISSN: 1638-6183 ; DOI: 10.1016/j.biochi.2014.10.021

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