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T Follicular Helper Cells Mediate Expansion of Regulatory B Cells via IL-21 in Lupus-Prone MRL/lpr Mice

Yang, Xue ; Yang, Ji ; Chu, Yiwei ; Wang, Jiucun ; Guan, Ming ; Zhu, Xiaoxia ; Xue, Yu ; Zou, Hejian; Bobé, Pierre

PLoS ONE, 4/24/2013, Vol.8(4), p.e62855 [Tạp chí có phản biện]

E-ISSN: 1932-6203 ; DOI: http://dx.doi.org/10.1371/journal.pone.0062855

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  • Nhan đề:
    T Follicular Helper Cells Mediate Expansion of Regulatory B Cells via IL-21 in Lupus-Prone MRL/lpr Mice
  • Tác giả: Yang, Xue ; Yang, Ji ; Chu, Yiwei ; Wang, Jiucun ; Guan, Ming ; Zhu, Xiaoxia ; Xue, Yu ; Zou, Hejian
  • Bobé, Pierre
  • Chủ đề: Research Article ; Biology ; Medicine
  • Là 1 phần của: PLoS ONE, 4/24/2013, Vol.8(4), p.e62855
  • Mô tả: T follicular helper (Tfh) cells can mediate humoral immune responses and augment autoimmunity, whereas the role of Tfh cells on regulatory B (B10) cells in autoimmunity diseases is not clear. Here, we investigated the percentages of Tfh cells and B10 cells in lupus-prone MRL/Mp-lpr/lpr (MRL/lpr) mice and examined the effects and mechanism of Tfh cell-derived interleukin-21 (IL-21) on IL-10 production during the differentiation of B10 cells. Both Tfh cells and B10 cells were expanded in spleens of MRL/lpr mice. In addition, a positive correlation between the proportions of Tfh cells and B10 cells was observed. Tfh cell-derived IL-21 from MRL/lpr mice could promote IL-10 production during the differentiation of B10 cells. Importantly, neutralization of IL-21 inhibited IL-10 production and expansion of B10 cells both in vitro and in vivo . IL-21 induced IL-10 production via activation of phosphorylated signal transduction and activator of transcription 3 (p-STAT3). Inhibition of p-STAT3 effectively blocked IL-10 production during the differentiation of B10 cells. Moreover, IL-21-induced IL-10 exerted a regulatory function by inhibiting the proliferation of T cells. These data suggest that Tfh cells not only mediate humoral immune responses and augment autoimmunity but also play a broader role in immune regulatory actions via the induction of IL-10 production.
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1932-6203 ; DOI: http://dx.doi.org/10.1371/journal.pone.0062855

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