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Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

Takeda, N. ; Jain, R. ; Leboeuf, M. R. ; Wang, Q. ; Lu, M. M. ; Epstein, J. A.

Science, 12/09/2011, Vol.334(6061), pp.1420-1424 [Tạp chí có phản biện]

ISSN: 0036-8075 ; E-ISSN: 1095-9203 ; DOI: http://dx.doi.org/10.1126/science.1213214

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  • Nhan đề:
    Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
  • Tác giả: Takeda, N. ; Jain, R. ; Leboeuf, M. R. ; Wang, Q. ; Lu, M. M. ; Epstein, J. A.
  • Chủ đề: Stem Cells ; Research
  • Là 1 phần của: Science, 12/09/2011, Vol.334(6061), pp.1420-1424
  • Mô tả: Stem cells in the intestine are responsible for the regular replacement of intestinal epithelium throughout life, as well as for recuperation after disease or injury. Two populations of intestinal stem cells have been identified, one in the base and one on the side of the intestinal crypt. Studying mice, Takeda et al. (p. 1420, published online 10 November) found that the relatively quiescent stem cells in the side of the crypt could give rise to the rapidly cycling stem cells in the base of the crypt, and the active cells could also give rise to the quiescent cells. Despite this ability to cross-populate one another, each group of stem cells, however, functions independently and has distinct characteristics. Intestinal epithelial stem cell identity and location have been the subject of substantial research. Cells in the +4 niche are slow-cycling and label-retaining, whereas a different stem cell niche located at the crypt base is occupied by crypt base columnar (CBC) cells. CBCs are distinct...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0036-8075 ; E-ISSN: 1095-9203 ; DOI: http://dx.doi.org/10.1126/science.1213214

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