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T cell vaccination does not induce resistance to experimental autoimmune neuritis

Jung, Stefan ; Schluesener, Hermann J. ; Toyka, Klaus ; Hartung, Hans-Peter

Journal of Neuroimmunology, 12/1991, Vol.35(1-3), pp.1-11 [Tạp chí có phản biện]

ISSN: 01655728 ; DOI: http://dx.doi.org/10.1016/0165-5728(91)90156-2

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  • Nhan đề:
    T cell vaccination does not induce resistance to experimental autoimmune neuritis
  • Tác giả: Jung, Stefan ; Schluesener, Hermann J. ; Toyka, Klaus ; Hartung, Hans-Peter
  • Chủ đề: Experimental Autoimmune Neuritis ; T Cell Vaccination
  • Là 1 phần của: Journal of Neuroimmunology, 12/1991, Vol.35(1-3), pp.1-11
  • Mô tả: The effectiveness of T cell vaccination was analyzed in experimental autoimmune neuritis (EAN) that can be induced by imminization with bovine P2 protein or a peptide representing the amino acids 53–78 of P2 (P2 53–78). Lewis rats were vaccinated with glutaraldehyde-fixed lymph node cells which had been primed in vivo with P2 protein or P2 53–78 and had been activated in vitro with concanavalin A. Vaccinated animals were not protected from EAN induced by immunization with P2 protein in complete Freund's adjuvant (CFA). In a second set of experiments Lewis rats were vaccinated with irradiated or fixed P2-specific T cell lines of different specificity and neuritogenicity and were subsequently challenged with P2 53–78 in CFA. Likewise, severity of P2 53–78-induced EAN was not different between naive and T line-vaccinated groups. In spleens of vaccinated animals a substantial suppressive activity was demonstrated which was positively correlated with a weak anti-ergotypic response of these spleen cells. The fact that development of actively induced EAN was not prevented or even mitigated by T cell vaccination, in spite of an apparent vaccination-induced response to and on T lymphocytes, suggests that protection from disease is not readily induced in every autoimmune disease model.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 01655728 ; DOI: http://dx.doi.org/10.1016/0165-5728(91)90156-2

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