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Gene expression profile changes in Eisenia fetida chronically exposed to PFOA

Mayilswami, Srinithi ; Krishnan, Kannan ; Megharaj, Mallavarapu ; Naidu, Ravi

Ecotoxicology, 2016, Vol.25(4), pp.759-769 [Tạp chí có phản biện]

ISSN: 0963-9292 ; E-ISSN: 1573-3017 ; DOI: 10.1007/s10646-016-1634-x

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  • Nhan đề:
    Gene expression profile changes in Eisenia fetida chronically exposed to PFOA
  • Tác giả: Mayilswami, Srinithi ; Krishnan, Kannan ; Megharaj, Mallavarapu ; Naidu, Ravi
  • Chủ đề: Eisenia fetida ; Perfluorooctanoic acid (PFOA) ; Transcriptome assembly ; Differential gene expression ; Toxicogenomics
  • Là 1 phần của: Ecotoxicology, 2016, Vol.25(4), pp.759-769
  • Mô tả: Eisenia fetida is a terrestrial organism, which can be used to diagnose sub-lethal concentrations of PFOA by using molecular biomarkers. In order to identify potential molecular biomarkers, we have exposed E.   fetida to 10 mg/kg of PFOA in soil for 8 months. The mRNA isolation, sequencing, transcriptome assembly followed by differential gene expression studies have revealed that genes that are involved in apoptotic process, reproduction, calcium signalling, neuronal development and lipid metabolism are predominantly affected. Highly specific genes that are altered by PFOA can be further validated and used as biomarker to detect sub-lethal concentrations of PFOA in the soil.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0963-9292 ; E-ISSN: 1573-3017 ; DOI: 10.1007/s10646-016-1634-x

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