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Geometric properties of a class of piecewise affine biological network models

Farcot, Etienne

Journal of Mathematical Biology, 2006, Vol.52(3), pp.373-418 [Tạp chí có phản biện]

ISSN: 0303-6812 ; E-ISSN: 1432-1416 ; DOI: 10.1007/s00285-005-0360-4

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  • Nhan đề:
    Geometric properties of a class of piecewise affine biological network models
  • Tác giả: Farcot, Etienne
  • Chủ đề: Gene and neural networks ; Piecewise-affine dynamical systems ; Symbolic dynamics
  • Là 1 phần của: Journal of Mathematical Biology, 2006, Vol.52(3), pp.373-418
  • Mô tả: The purpose of this report is to investigate some dynamical properties common to several biological systems. A model is chosen, which consists of a system of piecewise affine differential equations. Such a model has been previously studied in the context of gene regulation and neural networks, as well as biochemical kinetics. Unlike most of these studies, nonuniform decay rates and several thresholds per variable are assumed, thus considering a more realistic model. This model is investigated with the aid of a geometric formalism. We first provide an analysis of a continuous-space, discrete-time dynamical system equivalent to the initial one, by the way of a transition map. This is similar to former studies. Especially, the analysis of periodic trajectories is carried out in the case of multiple thresholds, thus extending previous results, which all concerned the restricted case of binary systems. The piecewise affine structure of such models is then used to provide a partition of the phase space, in terms of explicit cells. Allowed transitions between these cells define a language on a finite alphabet. Some words are proved to be forbidden in this language, thus improving the knowledge on such systems in terms of symbolic dynamics. More precisely, we show that taking these forbidden words into account leads to a dynamical system with strictly lower topological entropy. This holds for a class of systems, characterized by the presence of a splitting box, with additional conditions. We conclude after an illustrative three-dimensional example.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0303-6812 ; E-ISSN: 1432-1416 ; DOI: 10.1007/s00285-005-0360-4

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