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Heavy metals and couple fecundity, the LIFE Study

Buck Louis, Germaine M. ; Sundaram, Rajeshwari ; Schisterman, Enrique F. ; Sweeney, Anne M. ; Lynch, Courtney D. ; Gore-Langton, Robert E. ; Chen, Zhen ; Kim, Sungduk ; Caldwell, Kathleen L. ; Barr, Dana Boyd

Chemosphere, June 2012, Vol.87(11), pp.1201-1207 [Tạp chí có phản biện]

ISSN: 0045-6535 ; DOI: 10.1016/j.chemosphere.2012.01.017

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  • Nhan đề:
    Heavy metals and couple fecundity, the LIFE Study
  • Tác giả: Buck Louis, Germaine M. ; Sundaram, Rajeshwari ; Schisterman, Enrique F. ; Sweeney, Anne M. ; Lynch, Courtney D. ; Gore-Langton, Robert E. ; Chen, Zhen ; Kim, Sungduk ; Caldwell, Kathleen L. ; Barr, Dana Boyd
  • Chủ đề: Cd ; Ci ; FOR ; Hg ; Pb ; Ttp ; Cadmium ; Fecundity ; Lead ; Mercury ; Reproduction ; Time-to-Pregnancy
  • Là 1 phần của: Chemosphere, June 2012, Vol.87(11), pp.1201-1207
  • Mô tả: Highlights► Female cadmium and male lead blood concentrations associated with a longer time-to-pregnancy. ► Male blood lead effect remained in the context of female exposures. ► Environmentally-relevant concentrations of metals adversely affect couple fecundity. The effect of heavy metals at environmentally relevant concentrations on couple fecundity has received limited study despite ubiquitous exposure. In 2005–2009, couples (n=501) desiring pregnancy and discontinuing contraception were recruited and asked to complete interviews and to provide blood specimens for the quantification of cadmium (μgL−1), lead (μgdL−1) and mercury (μgL−1) using inductively coupled plasma-mass spectrometry. Couples completed daily journals on lifestyle and intercourse along with menstruation and pregnancy testing for women. Couples were followed for 12months or until pregnant. Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated adjusting for age, body mass index, cotinine, and serum lipids in relation to female then male exposures. FORs <1 denote a longer time to pregnancy. In adjusted models, reduced FORs were observed for both female cadmium (0.78; 95% CI 0.63–0.97) and male lead (0.85; 95% CI 0.73–0.98) concentrations. When jointly modeling couples’ exposures, only male lead concentration significantly reduced the FOR (0.82; 95% CI 0.68, 0.97), though the FOR remained <1 for female cadmium (0.80; 95% CI 0.64, 1.00). This prospective couple based cohort with longitudinal capture of time to pregnancy is suggestive of cadmium and lead’s reproductive toxicity at environmentally relevant concentrations.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0045-6535 ; DOI: 10.1016/j.chemosphere.2012.01.017

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