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Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal

Piochon, Claire ; Titley, H.K. ; Simmons, Dana H. ; Grasselli, G. ; Elgersma, Ype ; Hansel, Christian; Department of Neuroscience

Proceedings of the National Academy of Sciences of the United States of America, 2016, Vol.113(46), pp.13221-13226 [Tạp chí có phản biện]

ISSN: ; ISSN: 00278424

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  • Nhan đề:
    Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal
  • Tác giả: Piochon, Claire ; Titley, H.K. ; Simmons, Dana H. ; Grasselli, G. ; Elgersma, Ype ; Hansel, Christian
  • Department of Neuroscience
  • Chủ đề: Calcium/Calmodulin-Dependent Kinase Ii ; Cerebellum ; Long-Term Depression ; Long-Term Potentiation ; Purkinje Cell
  • Là 1 phần của: Proceedings of the National Academy of Sciences of the United States of America, 2016, Vol.113(46), pp.13221-13226
  • Mô tả: textabstractAt glutamatergic synapses, both long-term potentiation (LTP) and long-term depression (LTD) can be induced at the same synaptic activation frequency. Instructive signals determine whether LTP or LTD is induced, by modulating local calcium transients. Synapses maintain the ability to potentiate or depress over a wide frequency range, but it remains unknown how calcium-controlled plasticity operates when frequency variations alone cause differences in calcium amplitudes. We addressed this problem at cerebellar parallel fiber-Purkinje cell synapses, which can undergo LTD or LTP in response to 1-Hz and 100-Hz stimulation. We observed that high-frequency activation elicits larger spine calcium transients than low-frequency stimulation under all stimulus conditions, but, regardless of activation frequency, climbing fiber (CF) coactivation provides an instructive signal that further enhances calcium transients and promotes LTD. At both frequencies, buffering calcium prevents LTD induction...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: ; ISSN: 00278424

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