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A mechanism of retinoid potentiation of murine T-cell responses: early upregulation of interleukin-2 receptors

Jiang, X L ; Everson, M P ; Lamon, E W

International journal of immunopharmacology, April 1993, Vol.15(3), pp.309-17

ISSN: 0192-0561 ; PMID: 8505143 Version:1

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  • Nhan đề:
    A mechanism of retinoid potentiation of murine T-cell responses: early upregulation of interleukin-2 receptors
  • Tác giả: Jiang, X L ; Everson, M P ; Lamon, E W
  • Chủ đề: Receptors, Interleukin-2 -- Drug Effects ; Retinoids -- Pharmacology ; T-Lymphocytes -- Drug Effects
  • Là 1 phần của: International journal of immunopharmacology, April 1993, Vol.15(3), pp.309-17
  • Mô tả: The capacity of retinoids to amplify the proliferative response of BALB/c lymphocytes to concanavalin A (Con A)2 in the presence of exogenous interleukin-2 (IL-2) and the induction of IL-2 receptors (IL-2R) on L3T4+ and Lyt-2+ T-cells was evaluated. Preincubation with Con A for 8 h in the presence of retinoids resulted in a greater than two-fold increase in spleen cell proliferative response to Con A plus rIL-2 over the following 72 h relative to the response of cells preincubated with Con A alone. Peak potentiation of IL-2 responses occurred over a pharmacologic range of retinoic acid (RA) concentration (10(-10)-10(-8) M) in the presence of 20 U/ml rIL-2. This potentiation of the response to IL-2 was likewise observed after 8 h prestimulation with Con A with splenic T-cells enriched by passage over nylon wool. Preincubation of the spleen cells with Con A plus RA without the subsequent addition of IL-2 resulted in a proliferative response that was potentiated nearly to the level of the response produced by subsequent addition of IL-2 to Con A-activated cells. Preincubation of the cells with Con A in the presence of RA produced a true synergy with IL-2; the resulting increase in response was greater than the sum of the increases produced by RA or IL-2 alone.(ABSTRACT TRUNCATED AT 250 WORDS)
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0192-0561 ; PMID: 8505143 Version:1
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     ©2016 Library and Information Center, Vietnam National University, Hanoi. All Right Reserved.
  Nhà C1T, Đại học Quốc gia Hà Nội
144 Xuân Thủy, Cầu Giấy, Hà Nội
  (024) 3754 6545    lic@vnu.edu.vn

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