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A mechanism of retinoid potentiation of murine T-cell responses: early upregulation of interleukin-2 receptors

Jiang, X L ; Everson, M P ; Lamon, E W

International journal of immunopharmacology, April 1993, Vol.15(3), pp.309-17

ISSN: 0192-0561 ; PMID: 8505143 Version:1

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  • Nhan đề:
    A mechanism of retinoid potentiation of murine T-cell responses: early upregulation of interleukin-2 receptors
  • Tác giả: Jiang, X L ; Everson, M P ; Lamon, E W
  • Chủ đề: Receptors, Interleukin-2 -- Drug Effects ; Retinoids -- Pharmacology ; T-Lymphocytes -- Drug Effects
  • Là 1 phần của: International journal of immunopharmacology, April 1993, Vol.15(3), pp.309-17
  • Mô tả: The capacity of retinoids to amplify the proliferative response of BALB/c lymphocytes to concanavalin A (Con A)2 in the presence of exogenous interleukin-2 (IL-2) and the induction of IL-2 receptors (IL-2R) on L3T4+ and Lyt-2+ T-cells was evaluated. Preincubation with Con A for 8 h in the presence of retinoids resulted in a greater than two-fold increase in spleen cell proliferative response to Con A plus rIL-2 over the following 72 h relative to the response of cells preincubated with Con A alone. Peak potentiation of IL-2 responses occurred over a pharmacologic range of retinoic acid (RA) concentration (10(-10)-10(-8) M) in the presence of 20 U/ml rIL-2. This potentiation of the response to IL-2 was likewise observed after 8 h prestimulation with Con A with splenic T-cells enriched by passage over nylon wool. Preincubation of the spleen cells with Con A plus RA without the subsequent addition of IL-2 resulted in a proliferative response that was potentiated nearly to the level of the response produced by subsequent addition of IL-2 to Con A-activated cells. Preincubation of the cells with Con A in the presence of RA produced a true synergy with IL-2; the resulting increase in response was greater than the sum of the increases produced by RA or IL-2 alone.(ABSTRACT TRUNCATED AT 250 WORDS)
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0192-0561 ; PMID: 8505143 Version:1

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