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Glucose and lipid metabolism during acebutolol and propranolol therapy of angina in nondiabetic patients

Birnbaum, J ; Dibianco, R ; Becker, K L ; Muesing, R ; Costello, R B ; Singh, S N ; Gottdiener, J S ; Fletcher, R D

Clinical pharmacology and therapeutics, March 1983, Vol.33(3), pp.294-300 [Tạp chí có phản biện]

ISSN: 0009-9236 ; PMID: 6337762 Version:1

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  • Nhan đề:
    Glucose and lipid metabolism during acebutolol and propranolol therapy of angina in nondiabetic patients
  • Tác giả: Birnbaum, J ; Dibianco, R ; Becker, K L ; Muesing, R ; Costello, R B ; Singh, S N ; Gottdiener, J S ; Fletcher, R D
  • Chủ đề: Lipid Metabolism ; Acebutolol -- Therapeutic Use ; Angina Pectoris -- Drug Therapy ; Glucose -- Metabolism ; Propranolol -- Therapeutic Use
  • Là 1 phần của: Clinical pharmacology and therapeutics, March 1983, Vol.33(3), pp.294-300
  • Mô tả: The metabolic effects of acebutolol, a cardioselective beta-adrenergic blocker, and of propranolol, a nonselective beta blocker, were evaluated. Our subjects were 20 men with chronic stable angina; none had diabetes. An initial 4-wk, single-blind control phase was followed by two drug treatment periods, each a 3-wk double-blind titration phase (using increasing doses of acebutolol or propranolol), followed by a 5-wk double-blind maintenance phase. Metabolic studies were performed at the end of the control and maintenance phases. Propranolol induced elevation in basal serum glucose concentrations and both propranolol and acebutolol decreased glucose tolerance at 2.5 and 3 hr. There was no noticeable effect on insulin secretion by either drug. Neither propranolol nor acebutolol induced hyperlipidemia. There was a small decrease in total serum cholesterol after propranolol. Both drugs decreased low-density lipoprotein cholesterol. No effects were noted on the levels of serum triglycerides,...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0009-9236 ; PMID: 6337762 Version:1

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