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Efficacy and safety of esmolol vs propranolol in the treatment of supraventricular tachyarrhythmias: a multicenter double-blind clinical trial

Abrams, J ; Allen, J ; Allin, D ; Anderson, J ; Anderson, S ; Blanski, L ; Chadda, K ; Dibianco, R ; Favrot, L ; Gonzalez, J

American heart journal, November 1985, Vol.110(5), pp.913-22 [Tạp chí có phản biện]

ISSN: 0002-8703 ; PMID: 3904379 Version:1

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  • Nhan đề:
    Efficacy and safety of esmolol vs propranolol in the treatment of supraventricular tachyarrhythmias: a multicenter double-blind clinical trial
  • Tác giả: Abrams, J ; Allen, J ; Allin, D ; Anderson, J ; Anderson, S ; Blanski, L ; Chadda, K ; Dibianco, R ; Favrot, L ; Gonzalez, J
  • Chủ đề: Arrhythmias, Cardiac -- Drug Therapy ; Propanolamines -- Therapeutic Use ; Propranolol -- Therapeutic Use
  • Là 1 phần của: American heart journal, November 1985, Vol.110(5), pp.913-22
  • Mô tả: The efficacy and safety of intravenous esmolol infusion was compared to that of intravenous propranolol injection in patients with supraventricular tachyarrhythmias (SVT) in a multicenter double-blind parallel study. A total of 127 patients were randomized to either the esmolol (n = 64) or propranolol (n = 63) group. Therapeutic response was achieved in 72% of esmolol and 69% of propranolol patients (p = NS). The average dose of esmolol in responders was 115 +/- 11 micrograms/kg/min. Therapeutic response was sustained in the 4-hour maintenance period in 67% of esmolol and 58% of propranolol patients (p = NS). Rate of conversion to normal sinus rhythm was similar in the two treatment groups. After discontinuation, rapid recovery from beta blockade (decrease in heart rate reduction) was observed in esmolol patients (within 10 minutes) compared to propranolol patients (no change in heart rate up to 4.3 hours). The principal adverse effect was hypotension, reported in 23 esmolol (asymptomatic...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0002-8703 ; PMID: 3904379 Version:1

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