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Combination propranolol and bepridil therapy in stable angina pectoris

Frishman, W H ; Charlap, S ; Farnham, D J ; Sawin, H S ; Michelson, E L ; Crawford, M H ; Dibianco, R ; Kostis, J B ; Zellner, S R ; Michie, D D

The American journal of cardiology, 15 March 1985, Vol.55(7), pp.43C-49C [Tạp chí có phản biện]

ISSN: 0002-9149 ; PMID: 3883741 Version:1

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  • Nhan đề:
    Combination propranolol and bepridil therapy in stable angina pectoris
  • Tác giả: Frishman, W H ; Charlap, S ; Farnham, D J ; Sawin, H S ; Michelson, E L ; Crawford, M H ; Dibianco, R ; Kostis, J B ; Zellner, S R ; Michie, D D
  • Chủ đề: Angina Pectoris -- Drug Therapy ; Calcium Channel Blockers -- Administration & Dosage ; Propranolol -- Administration & Dosage ; Pyrrolidines -- Administration & Dosage
  • Là 1 phần của: The American journal of cardiology, 15 March 1985, Vol.55(7), pp.43C-49C
  • Mô tả: The safety and efficacy of bepridil plus propranolol therapy were investigated in a placebo-controlled, parallel-design, double-blind trial in 56 patients who were not responding to propranolol alone. Patients entering the study were receiving an average propranolol dosage of 131 mg/day (range 20 to 240). For the first 2 weeks of the study they were given placebo in addition to their propranolol dose, and then were randomized to receive continued placebo plus propranolol or bepridil plus propranolol therapy. The bepridil dosage was adjusted over the 8 weeks of active treatment to an average of 273 mg/day (range 200 to 400). The double-blind treatment period was followed by a 3-week washout period during which all patients received propranolol and placebo. The effects of treatment on the frequency of angina attacks, nitroglycerin consumption, exercise performance (treadmill-modified Bruce protocol) and Holter electrocardiogram (ECG) were assessed. Propranolol and bepridil plasma levels also...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0002-9149 ; PMID: 3883741 Version:1

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