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Preferential susceptibility of Th9 and Th2 CD4+ T cells to X4-tropic HIV-1 infection

Orlova-Fink, Nina ; Chowdhury, Fatema Z ; Sun, Xiaoming ; Harrington, Sean ; Rosenberg, Eric S ; Yu, Xu G ; Lichterfeld, Mathias

AIDS (London, England), 23 October 2017, Vol.31(16), pp.2211-2215 [Tạp chí có phản biện]

E-ISSN: 1473-5571 ; PMID: 28857825 Version:1 ; DOI: 10.1097/QAD.0000000000001630

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  • Nhan đề:
    Preferential susceptibility of Th9 and Th2 CD4+ T cells to X4-tropic HIV-1 infection
  • Tác giả: Orlova-Fink, Nina ; Chowdhury, Fatema Z ; Sun, Xiaoming ; Harrington, Sean ; Rosenberg, Eric S ; Yu, Xu G ; Lichterfeld, Mathias
  • Chủ đề: Viral Tropism ; HIV-1 -- Growth & Development ; Receptors, Cxcr4 -- Metabolism ; Receptors, HIV -- Metabolism ; T-Lymphocyte Subsets -- Virology ; T-Lymphocytes, Helper-Inducer -- Virology
  • Là 1 phần của: AIDS (London, England), 23 October 2017, Vol.31(16), pp.2211-2215
  • Mô tả: The functional polarization of CD4 T cells determines their antimicrobial effector profile, but may also impact the susceptibility to infection with HIV-1. Here, we analyzed the susceptibility of CD4 T cells with different functional polarization to infection with X4 and R5-tropic HIV-1. CD4 T cells with a Th1, Th2, Th17, and Th9 polarization were subjected to in-vitro infection assays with X4, R5, or vesicular stomatitis virus-G protein-pseudotyped HIV-1. In addition, we sorted differentially polarized CD4 T-cell subsets from individuals treated with antiretroviral therapy and analyzed the tropism of viral env sequences. Th9-polarized CD4 T cells and, to a lesser extent, Th2-polarized CD4 T cells expressed higher surface levels of CXCR4, and are more permissive to X4-tropic infection in vitro. In contrast, Th1 and Th17 CD4 T cells exhibited stronger surface expression of CCR5, and were more susceptible to infection with R5-tropic viruses. Correspondingly, the distribution of X4-tropic viral sequences in antiretroviral therapy-treated HIV-1-infected patients was biased toward Th9/Th2 cells, whereas R5-tropic sequences were more frequently observed in Th17 cells. CD4 T-cell polarization is associated with a distinct susceptibility to X4 and R5-tropic HIV-1 infection.
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1473-5571 ; PMID: 28857825 Version:1 ; DOI: 10.1097/QAD.0000000000001630

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