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HLA-G+ HIV-1-specific CD8+ T cells are associated with HIV-1 immune control

Viganò, Selena ; Negrón, Jordi J ; Tse, Samantha ; Chowdhury, Fatema Z ; Lichterfeld, Mathias ; Yu, Xu G

AIDS (London, England), 14 January 2017, Vol.31(2), pp.207-212 [Tạp chí có phản biện]

E-ISSN: 1473-5571 ; PMID: 27835619 Version:1 ; DOI: 10.1097/QAD.0000000000001326

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  • Nhan đề:
    HLA-G+ HIV-1-specific CD8+ T cells are associated with HIV-1 immune control
  • Tác giả: Viganò, Selena ; Negrón, Jordi J ; Tse, Samantha ; Chowdhury, Fatema Z ; Lichterfeld, Mathias ; Yu, Xu G
  • Chủ đề: Cd8-Positive T-Lymphocytes -- Chemistry ; HIV Infections -- Immunology ; HLA-G Antigens -- Analysis ; T-Lymphocyte Subsets -- Chemistry
  • Là 1 phần của: AIDS (London, England), 14 January 2017, Vol.31(2), pp.207-212
  • Mô tả: To assess the frequency and function of HIV-1-specific HLA-G (histocompatibility antigen class I, G) CD8 T cells in HIV-1 controllers and progressors. We performed an observational cross-sectional cohort analysis in untreated (n = 47) and treated (n = 17) HIV-1 patients with different rates of disease progression and n = 14 healthy individuals. We evaluated the frequency, the proportion and the function of total and virus-specific HLA-G CD8 T cells by tetramer or intracellular cytokine staining, followed by flow cytometric analysis. Cytokine secretion of sorted CD8 T-cell subsets was evaluated by Luminex assays. The proportion and the absolute frequency of HLA-G HIV-1-specific CD8 T cells were directly associated with CD4 T-cell counts and inversely correlated with viral loads, whereas total or HLA-G-negative HIV-1-specific CD8 T cells were not. In functional assays, HLA-G CD8 T cells from HIV-1-negative individuals had higher abilities to produce the antiviral (C-C chemokine receptor type 5) ligands MIP-1β (macrophage inflammatory protein-1ß), MIP-1α and Rantes. HLA-G HIV-1-specific CD8 T cells may represent a previously unrecognized correlate of HIV-1 immune control.
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1473-5571 ; PMID: 27835619 Version:1 ; DOI: 10.1097/QAD.0000000000001326

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