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3Disease Browser: A Web server for integrating 3D genome and disease-associated chromosome rearrangement data

Li, Ruifeng ; Liu, Yifang ; Li, Tingting ; Li, Cheng

Scientific reports, 13 October 2016, Vol.6, pp.34651 [Tạp chí có phản biện]

E-ISSN: 2045-2322 ; PMID: 27734896 Version:1 ; DOI: 10.1038/srep34651

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  • Nhan đề:
    3Disease Browser: A Web server for integrating 3D genome and disease-associated chromosome rearrangement data
  • Tác giả: Li, Ruifeng ; Liu, Yifang ; Li, Tingting ; Li, Cheng
  • Chủ đề: Chromosome Aberrations ; Web Browser ; Computational Biology -- Methods ; Disease -- Genetics ; Genome -- Genetics
  • Là 1 phần của: Scientific reports, 13 October 2016, Vol.6, pp.34651
  • Mô tả: Chromosomal rearrangement (CR) events have been implicated in many tumor and non-tumor human diseases. CR events lead to their associated diseases by disrupting gene and protein structures. Also, they can lead to diseases through changes in chromosomal 3D structure and gene expression. In this study, we search for CR-associated diseases potentially caused by chromosomal 3D structure alteration by integrating Hi-C and ChIP-seq data. Our algorithm rediscovers experimentally verified disease-associated CRs (polydactyly diseases) that alter gene expression by disrupting chromosome 3D structure. Interestingly, we find that intellectual disability may be a candidate disease caused by 3D chromosome structure alteration. We also develop a Web server (3Disease Browser, http://3dgb.cbi.pku.edu.cn/disease/) for integrating and visualizing disease-associated CR events and chromosomal 3D structure.
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 2045-2322 ; PMID: 27734896 Version:1 ; DOI: 10.1038/srep34651

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