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Intrafollicular expression and potential regulatory role of cocaine- and amphetamine-regulated transcript in the ovine ovary

Huang, Y ; Yao, X L ; Meng, J Z ; Liu, Y ; Jiang, X L ; Chen, J W ; Li, P F ; Ren, Y S ; Liu, W Z ; Yao, J B ; Folger, J K ; Smith, G W ; Lv, L H

Domestic animal endocrinology, January 2016, Vol.54, pp.30-6 [Tạp chí có phản biện]

E-ISSN: 1879-0054 ; PMID: 26490113 Version:1 ; DOI: 10.1016/j.domaniend.2015.09.001

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  • Nhan đề:
    Intrafollicular expression and potential regulatory role of cocaine- and amphetamine-regulated transcript in the ovine ovary
  • Tác giả: Huang, Y ; Yao, X L ; Meng, J Z ; Liu, Y ; Jiang, X L ; Chen, J W ; Li, P F ; Ren, Y S ; Liu, W Z ; Yao, J B ; Folger, J K ; Smith, G W ; Lv, L H
  • Chủ đề: Cart ; Estradiol ; Follicle ; Granulosal Cell ; Sheep ; Gene Expression ; Nerve Tissue Proteins -- Genetics ; Ovarian Follicle -- Metabolism ; Sheep -- Metabolism
  • Là 1 phần của: Domestic animal endocrinology, January 2016, Vol.54, pp.30-6
  • Mô tả: Follicular growth is regulated by a complex interaction of pituitary gonadotropins with local regulatory molecules. Previous studies demonstrated an important role for cocaine- and amphetamine-regulated transcript (CART) in regulation of granulosa cell estradiol production associated with dominant follicle selection in cattle. However, intraovarian expression and actions of CART in other species, including sheep, are not known. The objective of this study was to investigate the expression of CART in sheep follicles and determine the effects of CART on indices of ovine granulosa cell function linked to follicular development. Results demonstrated the expression of CART messenger RNA and prominent intraovarian localization of CART peptide in granulosa cells of sheep follicles. Granulosa cell CART messenger RNA was lower, but follicular fluid estradiol concentrations were higher in large (>5 mm) follicles vs smaller 3- to 5-mm follicles harvested from sheep ovaries of abattoir origin. CART...
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1879-0054 ; PMID: 26490113 Version:1 ; DOI: 10.1016/j.domaniend.2015.09.001

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