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Mutations in global regulators lead to metabolic selection during adaptation to complex environments

Saxer, Gerda ; Krepps, Michael D ; Merkley, Eric D ; Ansong, Charles ; Deatherage Kaiser, Brooke L ; Valovska, Marie-Thérèse ; Ristic, Nikola ; Yeh, Ping T ; Prakash, Vittal P ; Leiser, Owen P ; Nakhleh, Luay ; Gibbons, Henry S ; Kreuzer, Helen W ; Shamoo, Yousif

PLoS genetics, December 2014, Vol.10(12), pp.e1004872 [Tạp chí có phản biện]

E-ISSN: 1553-7404 ; PMID: 25501822 Version:1 ; DOI: 10.1371/journal.pgen.1004872

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  • Nhan đề:
    Mutations in global regulators lead to metabolic selection during adaptation to complex environments
  • Tác giả: Saxer, Gerda ; Krepps, Michael D ; Merkley, Eric D ; Ansong, Charles ; Deatherage Kaiser, Brooke L ; Valovska, Marie-Thérèse ; Ristic, Nikola ; Yeh, Ping T ; Prakash, Vittal P ; Leiser, Owen P ; Nakhleh, Luay ; Gibbons, Henry S ; Kreuzer, Helen W ; Shamoo, Yousif
  • Chủ đề: Evolution, Molecular ; Citrobacter Freundii -- Genetics ; Escherichia Coli -- Genetics
  • Là 1 phần của: PLoS genetics, December 2014, Vol.10(12), pp.e1004872
  • Mô tả: Adaptation to ecologically complex environments can provide insights into the evolutionary dynamics and functional constraints encountered by organisms during natural selection. Adaptation to a new environment with abundant and varied resources can be difficult to achieve by small incremental changes if many mutations are required to achieve even modest gains in fitness. Since changing complex environments are quite common in nature, we investigated how such an epistatic bottleneck can be avoided to allow rapid adaptation. We show that adaptive mutations arise repeatedly in independently evolved populations in the context of greatly increased genetic and phenotypic diversity. We go on to show that weak selection requiring substantial metabolic reprogramming can be readily achieved by mutations in the global response regulator arcA and the stress response regulator rpoS. We identified 46 unique single-nucleotide variants of arcA and 18 mutations in rpoS, nine of which resulted in stop codons...
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1553-7404 ; PMID: 25501822 Version:1 ; DOI: 10.1371/journal.pgen.1004872

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