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BMP-2 and titanium particles synergistically activate osteoclast formation

Sun, S X ; Guo, H H ; Zhang, J ; Yu, B ; Sun, K N ; Jin, Q H

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, June 2014, Vol.47(6), pp.461-9 [Tạp chí có phản biện]

E-ISSN: 1414-431X ; PMID: 24820069 Version:1

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  • Nhan đề:
    BMP-2 and titanium particles synergistically activate osteoclast formation
  • Tác giả: Sun, S X ; Guo, H H ; Zhang, J ; Yu, B ; Sun, K N ; Jin, Q H
  • Chủ đề: Bone Morphogenetic Protein 2 -- Pharmacology ; Cell Differentiation -- Drug Effects ; Macrophages -- Drug Effects ; Osteoclasts -- Metabolism ; Rank Ligand -- Pharmacology ; Titanium -- Pharmacology
  • Là 1 phần của: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, June 2014, Vol.47(6), pp.461-9
  • Mô tả: A previous study showed that BMP-2 (bone morphogenetic protein-2) and wear debris can separately support osteoclast formation induced by the receptor activator of NF-κB ligand (RANKL). However, the effect of BMP-2 on wear debris-induced osteoclast formation is unclear. In this study, we show that neither titanium particles nor BMP-2 can induce osteoclast formation in RAW 264.7 mouse leukemic monocyte macrophage cells but that BMP-2 synergizes with titanium particles to enhance osteoclast formation in the presence of RANKL, and that at a low concentration, BMP-2 has an optimal effect to stimulate the size and number of multinuclear osteoclasts, expression of osteoclast genes, and resorption area. Our data also clarify that the effects caused by the increase in BMP-2 on phosphorylated SMAD levels such as c-Fos expression increased throughout the early stages of osteoclastogenesis. BMP-2 and titanium particles stimulate the expression of p-JNK, p-P38, p-IkB, and P50 compared with the titanium...
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1414-431X ; PMID: 24820069 Version:1

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