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T follicular helper cells mediate expansion of regulatory B cells via IL-21 in Lupus-prone MRL/lpr mice

Yang, Xue ; Yang, Ji ; Chu, Yiwei ; Wang, Jiucun ; Guan, Ming ; Zhu, Xiaoxia ; Xue, Yu ; Zou, Hejian

PloS one, 2013, Vol.8(4), pp.e62855 [Tạp chí có phản biện]

E-ISSN: 1932-6203 ; PMID: 23638156 Version:1 ; DOI: 10.1371/journal.pone.0062855

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  • Nhan đề:
    T follicular helper cells mediate expansion of regulatory B cells via IL-21 in Lupus-prone MRL/lpr mice
  • Tác giả: Yang, Xue ; Yang, Ji ; Chu, Yiwei ; Wang, Jiucun ; Guan, Ming ; Zhu, Xiaoxia ; Xue, Yu ; Zou, Hejian
  • Chủ đề: B-Lymphocytes, Regulatory -- Immunology ; Interleukins -- Metabolism ; T-Lymphocytes, Helper-Inducer -- Immunology
  • Là 1 phần của: PloS one, 2013, Vol.8(4), pp.e62855
  • Mô tả: T follicular helper (Tfh) cells can mediate humoral immune responses and augment autoimmunity, whereas the role of Tfh cells on regulatory B (B10) cells in autoimmunity diseases is not clear. Here, we investigated the percentages of Tfh cells and B10 cells in lupus-prone MRL/Mp-lpr/lpr (MRL/lpr) mice and examined the effects and mechanism of Tfh cell-derived interleukin-21 (IL-21) on IL-10 production during the differentiation of B10 cells. Both Tfh cells and B10 cells were expanded in spleens of MRL/lpr mice. In addition, a positive correlation between the proportions of Tfh cells and B10 cells was observed. Tfh cell-derived IL-21 from MRL/lpr mice could promote IL-10 production during the differentiation of B10 cells. Importantly, neutralization of IL-21 inhibited IL-10 production and expansion of B10 cells both in vitro and in vivo. IL-21 induced IL-10 production via activation of phosphorylated signal transduction and activator of transcription 3 (p-STAT3). Inhibition of p-STAT3 effectively...
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1932-6203 ; PMID: 23638156 Version:1 ; DOI: 10.1371/journal.pone.0062855

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