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Identification of copy number variants in horses

Doan, Ryan ; Cohen, Noah ; Harrington, Jessica ; Veazey, Kylee ; Veazy, Kylee ; Juras, Rytis ; Cothran, Gus ; Mccue, Molly E ; Skow, Loren ; Dindot, Scott V

Genome research, May 2012, Vol.22(5), pp.899-907 [Tạp chí có phản biện]

E-ISSN: 1549-5469 ; PMID: 22383489 Version:1 ; DOI: 10.1101/gr.128991.111

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  • Nhan đề:
    Identification of copy number variants in horses
  • Tác giả: Doan, Ryan ; Cohen, Noah ; Harrington, Jessica ; Veazey, Kylee ; Veazy, Kylee ; Juras, Rytis ; Cothran, Gus ; Mccue, Molly E ; Skow, Loren ; Dindot, Scott V
  • Chủ đề: DNA Copy Number Variations ; Horses -- Genetics
  • Là 1 phần của: Genome research, May 2012, Vol.22(5), pp.899-907
  • Mô tả: Copy number variants (CNVs) represent a substantial source of genetic variation in mammals. However, the occurrence of CNVs in horses and their subsequent impact on phenotypic variation is unknown. We performed a study to identify CNVs in 16 horses representing 15 distinct breeds (Equus caballus) and an individual gray donkey (Equus asinus) using a whole-exome tiling array and the array comparative genomic hybridization methodology. We identified 2368 CNVs ranging in size from 197 bp to 3.5 Mb. Merging identical CNVs from each animal yielded 775 CNV regions (CNVRs), involving 1707 protein- and RNA-coding genes. The number of CNVs per animal ranged from 55 to 347, with median and mean sizes of CNVs of 5.3 kb and 99.4 kb, respectively. Approximately 6% of the genes investigated were affected by a CNV. Biological process enrichment analysis indicated CNVs primarily affected genes involved in sensory perception, signal transduction, and metabolism. CNVs also were identified in genes regulating...
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1549-5469 ; PMID: 22383489 Version:1 ; DOI: 10.1101/gr.128991.111

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