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The selective footprints of viral pressures at the human RIG-I-like receptor family

Vasseur, Estelle ; Patin, Etienne ; Laval, Guillaume ; Pajon, Sandra ; Fornarino, Simona ; Crouau-Roy, Brigitte ; Quintana-Murci, Lluis

Human molecular genetics, 15 November 2011, Vol.20(22), pp.4462-74 [Tạp chí có phản biện]

E-ISSN: 1460-2083 ; PMID: 21865300 Version:1 ; DOI: 10.1093/hmg/ddr377

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  • Nhan đề:
    The selective footprints of viral pressures at the human RIG-I-like receptor family
  • Tác giả: Vasseur, Estelle ; Patin, Etienne ; Laval, Guillaume ; Pajon, Sandra ; Fornarino, Simona ; Crouau-Roy, Brigitte ; Quintana-Murci, Lluis
  • Chủ đề: Dead-Box RNA Helicases -- Genetics ; RNA Helicases -- Genetics ; Selection, Genetic -- Genetics
  • Là 1 phần của: Human molecular genetics, 15 November 2011, Vol.20(22), pp.4462-74
  • Mô tả: The RIG-I-like receptors (RLRs)--RIG-I, IFIH1 (or MDA5) and LGP2--are thought to be key actors in the innate immune system, as they play a major role in sensing RNA viruses in the cytosol of host cells. Despite the increasingly recognized importance of the RLR family in antiviral immunity, no population genetic studies have yet attempted to compare the evolutionary history of its different members in humans. Here, we characterized the levels of naturally occurring genetic variation in the RLRs in a panel of individuals of different ethnic origins, to assess to what extent natural selection has acted on this family of microbial sensors. Our results show that amino acid-altering variation at RIG-I, particularly in the helicase domain, has been under stronger evolutionary constraint than that at IFIH1 and LGP2, reflecting an important role for RIG-I in sensing numerous RNA viruses and/or functional constraints related to the binding of viral substrates. Such evolutionary constraints have been...
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1460-2083 ; PMID: 21865300 Version:1 ; DOI: 10.1093/hmg/ddr377

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