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Genome-wide recombination drives diversification of epidemic strains of Acinetobacter baumannii

Snitkin, Evan S ; Zelazny, Adrian M ; Montero, Clemente I ; Stock, Frida ; Mijares, Lilia ; Murray, Patrick R ; Segre, Julie A

Proceedings of the National Academy of Sciences of the United States of America, 16 August 2011, Vol.108(33), pp.13758-63 [Tạp chí có phản biện]

E-ISSN: 1091-6490 ; PMID: 21825119 Version:1 ; DOI: 10.1073/pnas.1104404108

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  • Nhan đề:
    Genome-wide recombination drives diversification of epidemic strains of Acinetobacter baumannii
  • Tác giả: Snitkin, Evan S ; Zelazny, Adrian M ; Montero, Clemente I ; Stock, Frida ; Mijares, Lilia ; Murray, Patrick R ; Segre, Julie A
  • Chủ đề: Recombination, Genetic ; Acinetobacter Baumannii -- Genetics ; Genome, Bacterial -- Genetics
  • Là 1 phần của: Proceedings of the National Academy of Sciences of the United States of America, 16 August 2011, Vol.108(33), pp.13758-63
  • Mô tả: Acinetobacter baumannii is an emerging human pathogen and a significant cause of nosocomial infections among hospital patients worldwide. The enormous increase in multidrug resistance among hospital isolates and the recent emergence of pan-drug-resistant strains underscores the urgency to understand how A. baumannii evolves in hospital environments. To this end, we undertook a genomic study of a polyclonal outbreak of multidrug-resistant A. baumannii at the research-based National Institutes of Health Clinical Center. Comparing the complete genome sequences of the three dominant outbreak strain types enabled us to conclude that, despite all belonging to the same epidemic lineage, the three strains diverged before their arrival at the National Institutes of Health. The simultaneous presence of three divergent strains from this lineage supports its increasing prevalence in international hospitals and suggests an ongoing adaptation to the hospital environment. Further genomic comparisons uncovered...
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1091-6490 ; PMID: 21825119 Version:1 ; DOI: 10.1073/pnas.1104404108

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