skip to main content
Ngôn ngữ:
Giới hạn tìm kiếm: Giới hạn tìm kiếm: Dạng tài nguyên Hiển thị kết quả với: Hiển thị kết quả với: Chỉ mục

Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis

Walsh, N ; Kennedy, S ; Larkin, A M ; Tryfonopoulos, D ; Eustace, A J ; Mahgoub, T ; Conway, C ; Oglesby, I ; Collins, D ; Ballot, J ; Ooi, W S ; Gullo, G ; Clynes, M ; Crown, J ; O'Driscoll, L

British journal of cancer, 30 March 2010, Vol.102(7), pp.1157-62 [Tạp chí có phản biện]

E-ISSN: 1532-1827 ; PMID: 20234362 Version:1 ; DOI: 10.1038/sj.bjc.6605590

Toàn văn sẵn có

Trích dẫn Trích dẫn bởi
  • Nhan đề:
    Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis
  • Tác giả: Walsh, N ; Kennedy, S ; Larkin, A M ; Tryfonopoulos, D ; Eustace, A J ; Mahgoub, T ; Conway, C ; Oglesby, I ; Collins, D ; Ballot, J ; Ooi, W S ; Gullo, G ; Clynes, M ; Crown, J ; O'Driscoll, L
  • Chủ đề: ATP Binding Cassette Transporter, Subfamily B, Member 1 -- Metabolism ; Melanoma -- Pathology ; Multidrug Resistance-Associated Proteins -- Metabolism
  • Là 1 phần của: British journal of cancer, 30 March 2010, Vol.102(7), pp.1157-62
  • Mô tả: Malignant melanoma, generally described as incurable, is notoriously refractory to chemotherapy. The mechanisms contributing to this have not yet been defined and the contributions of drug efflux pumps, implicated in chemo-resistance of many other cancer types, have not been extensively investigated in melanoma. In this study, expression of multi-drug resistant (MDR1/P-gp and MRP-1) proteins was examined, by immunohistochemistry, in archival specimens from 134 melanoma patients. This included 92 primary tumours and 42 metastases. On assessing all specimens, MRP-1 and MDR1/P-gp expression was found to be common, with the majority (81%) of melanomas expressing at least one of these efflux pumps. Although there is significant association between expression of these pumps (P=0.007), MRP-1 was found to be the predominant (67% of cases) form detected. chi(2) analysis showed significant associations between expression of MRP-1 and/or MDR1/P-gp and the aggressive nature of this disease specifically increased Breslow's depth, Clark's level and spread to lymph nodes. This association with aggressiveness and spread is further supported by the observation that a significantly higher percentage of metastases, than primary tumours, express MRP-1 (91% vs 57%; P<0.0001) and MDR1/P-gp (74% vs 50%; P=0.010). The predominant expression of these pumps and, in particular, MRP-1 suggests that they may be important contributors to the inherent aggressive and resistant nature of malignant melanoma.
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1532-1827 ; PMID: 20234362 Version:1 ; DOI: 10.1038/sj.bjc.6605590

Đang tìm Cơ sở dữ liệu bên ngoài...