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Time lines of infection and disease in human influenza: a review of volunteer challenge studies

Carrat, Fabrice ; Vergu, Elisabeta ; Ferguson, Neil M ; Lemaitre, Magali ; Cauchemez, Simon ; Leach, Steve ; Valleron, Alain-Jacques

American journal of epidemiology, 01 April 2008, Vol.167(7), pp.775-85 [Tạp chí có phản biện]

E-ISSN: 1476-6256 ; PMID: 18230677 Version:1 ; DOI: 10.1093/aje/kwm375

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  • Nhan đề:
    Time lines of infection and disease in human influenza: a review of volunteer challenge studies
  • Tác giả: Carrat, Fabrice ; Vergu, Elisabeta ; Ferguson, Neil M ; Lemaitre, Magali ; Cauchemez, Simon ; Leach, Steve ; Valleron, Alain-Jacques
  • Chủ đề: Virus Shedding ; Influenza A Virus, H1n1 Subtype -- Pathogenicity ; Influenza A Virus, H3n2 Subtype -- Pathogenicity ; Influenza B Virus -- Pathogenicity ; Influenza, Human -- Immunology
  • Là 1 phần của: American journal of epidemiology, 01 April 2008, Vol.167(7), pp.775-85
  • Mô tả: The dynamics of viral shedding and symptoms following influenza virus infection are key factors when considering epidemic control measures. The authors reviewed published studies describing the course of influenza virus infection in placebo-treated and untreated volunteers challenged with wild-type influenza virus. A total of 56 different studies with 1,280 healthy participants were considered. Viral shedding increased sharply between 0.5 and 1 day after challenge and consistently peaked on day 2. The duration of viral shedding averaged over 375 participants was 4.80 days (95% confidence interval: 4.31, 5.29). The frequency of symptomatic infection was 66.9% (95% confidence interval: 58.3, 74.5). Fever was observed in 37.0% of A/H1N1, 40.6% of A/H3N2 (p = 0.86), and 7.5% of B infections (p = 0.001). The total symptoms scores increased on day 1 and peaked on day 3. Systemic symptoms peaked on day 2. No such data exist for children or elderly subjects, but epidemiologic studies suggest that...
  • Ngôn ngữ: English
  • Số nhận dạng: E-ISSN: 1476-6256 ; PMID: 18230677 Version:1 ; DOI: 10.1093/aje/kwm375

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