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T cell vaccination does not induce resistance to experimental autoimmune neuritis

Jung, S ; Schluesener, H J ; Toyka, K ; Hartung, H P

Journal of neuroimmunology, December 1991, Vol.35(1-3), pp.1-11 [Tạp chí có phản biện]

ISSN: 0165-5728 ; PMID: 1720130 Version:1

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  • Nhan đề:
    T cell vaccination does not induce resistance to experimental autoimmune neuritis
  • Tác giả: Jung, S ; Schluesener, H J ; Toyka, K ; Hartung, H P
  • Chủ đề: Vaccination ; Neuritis, Autoimmune, Experimental -- Prevention & Control ; T-Lymphocytes -- Immunology
  • Là 1 phần của: Journal of neuroimmunology, December 1991, Vol.35(1-3), pp.1-11
  • Mô tả: The effectiveness of T cell vaccination was analyzed in experimental autoimmune neuritis (EAN) that can be induced by immunization with bovine P2 protein or a peptide representing the amino acids 53-78 of P2 (P2 53-78). Lewis rats were vaccinated with glutaraldehyde-fixed lymph node cells which had been primed in vivo with P2 protein or P2 53-78 and had been activated in vitro with concanavalin A. Vaccinated animals were not protected from EAN induced by immunization with P2 protein in complete Freund's adjuvant (CFA). In a second set of experiments Lewis rats were vaccinated with irradiated or fixed P2-specific T cell lines of different specificity and neuritogenicity and were subsequently challenged with P2 53-78 in CFA. Likewise, severity of P2 53-78-induced EAN was not different between naive and T line-vaccinated groups. In spleens of vaccinated animals a substantial suppressive activity was demonstrated which was positively correlated with a weak anti-ergotypic response of these spleen...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0165-5728 ; PMID: 1720130 Version:1

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