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Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice

Zhang, Y ; Schlossman, S F ; Edwards, R A ; Ou, Ching-Nan ; Gu, J ; Wu, Mei X

Proceedings of the National Academy of Sciences of the United States of America, 22 January 2002, Vol.99(2), pp.878-83 [Tạp chí có phản biện]

ISSN: 0027-8424 ; PMID: 11782530 Version:1

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  • Nhan đề:
    Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
  • Tác giả: Zhang, Y ; Schlossman, S F ; Edwards, R A ; Ou, Ching-Nan ; Gu, J ; Wu, Mei X
  • Chủ đề: Neoplasm Proteins ; Apoptosis -- Genetics ; Autoimmune Diseases -- Genetics ; Immediate-Early Proteins -- Genetics ; Lymphocyte Activation -- Genetics ; Membrane Glycoproteins -- Genetics
  • Là 1 phần của: Proceedings of the National Academy of Sciences of the United States of America, 22 January 2002, Vol.99(2), pp.878-83
  • Mô tả: Susceptibility of activated T cells to apoptosis must be tightly regulated to ensure sufficient T cell progeny for an effective response, while allowing a rapid depletion of them at the end of the immune response. We show here that a previously isolated, NF-kappa B/rel target gene IEX-1 (Immediate Early response gene X-1) is highly expressed in T cells at early stages of activation, but declines with a prolonged period of activation time, coincident with an increased susceptibility of T cells to apoptosis during the late phases of an immune response. Transgenic expression of IEX-1 specifically in lymphocytes impaired apoptosis in activated T cells, extended a duration of an effector-phase of a specific immune response, and increased the accumulation of effector/memory-like T cells and the susceptibility to a lupus-like autoimmune disease. Our study demonstrated an antiapoptotic effect of IEX-1 on T cell apoptosis triggered by ligation of Fas and T cell receptor (TCR)/CD3 complex. The ability of extending life expectancy of T effectors, in line with a decrease in its expression following prolonged T cell activation, suggests a key role for IEX-1 in regulating T cell homeostasis during immune responses.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0027-8424 ; PMID: 11782530 Version:1

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