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Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis

Zhang, Y ; Wang, H ; Toratani, S ; Sato, J D ; Kan, M ; Mckeehan, W L ; Okamoto, T

Proceedings of the National Academy of Sciences of the United States of America, 25 September 2001, Vol.98(20), pp.11336-40 [Tạp chí có phản biện]

ISSN: 0027-8424 ; PMID: 11562460 Version:1

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  • Nhan đề:
    Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis
  • Tác giả: Zhang, Y ; Wang, H ; Toratani, S ; Sato, J D ; Kan, M ; Mckeehan, W L ; Okamoto, T
  • Chủ đề: Adenocarcinoma -- Pathology ; Epithelial Cells -- Cytology ; Receptors, Fibroblast Growth Factor -- Physiology ; Salivary Gland Neoplasms -- Pathology ; Submandibular Gland -- Cytology
  • Là 1 phần của: Proceedings of the National Academy of Sciences of the United States of America, 25 September 2001, Vol.98(20), pp.11336-40
  • Mô tả: We have reported that normal human salivary gland-derived epithelial cells exclusively express keratinocyte growth factor receptor (KGFR). In the process of malignant transformation of human salivary gland tumors, KGFR gene expression disappeared concomitantly with the de novo expression of the fibroblast growth factor receptor 1 (FGFR1) and FGFR4 genes. In the present study, we introduced wild-type KGFR cDNA or chimeric KGFR/FGFR1 cDNA, which encoded the extracellular domain of KGFR and the intracellular domain of FGFR1, into the HSY human salivary adenocarcinoma cell line. The KGFR tyrosine kinase suppressed the activity of FGF receptor substrate 2 (FRS2) and inhibited the growth of HSY by inducing differentiation and apoptosis in vitro and in vivo. Our results provided significant insight into the mechanism of KGFR tumor suppression and suggest that KGFR gene therapy might be a viable method of inhibiting human salivary adenocarcinoma growth.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0027-8424 ; PMID: 11562460 Version:1

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