skip to main content
Ngôn ngữ:
Giới hạn tìm kiếm: Giới hạn tìm kiếm: Dạng tài nguyên Hiển thị kết quả với: Hiển thị kết quả với: Chỉ mục

Effects of parenteral nutrition supplemented with glutamine or glutamine dipeptides on liver antioxidant and detoxication systems in rats

Matilla, B ; Ortíz, J ; González, P ; García-Díez, F ; Jorquera, F ; Culebras, J M ; González-Gallego, J ; Tuñón, M J

Nutrition (Burbank, Los Angeles County, Calif.), February 2000, Vol.16(2), pp.125-8 [Tạp chí có phản biện]

ISSN: 0899-9007 ; PMID: 10696636 Version:1

Toàn văn sẵn có

Trích dẫn Trích dẫn bởi
  • Nhan đề:
    Effects of parenteral nutrition supplemented with glutamine or glutamine dipeptides on liver antioxidant and detoxication systems in rats
  • Tác giả: Matilla, B ; Ortíz, J ; González, P ; García-Díez, F ; Jorquera, F ; Culebras, J M ; González-Gallego, J ; Tuñón, M J
  • Chủ đề: Parenteral Nutrition, Total ; Antioxidants -- Metabolism ; Dipeptides -- Administration & Dosage ; Glutamine -- Administration & Dosage ; Liver -- Metabolism
  • Là 1 phần của: Nutrition (Burbank, Los Angeles County, Calif.), February 2000, Vol.16(2), pp.125-8
  • Mô tả: Our aim was to determine the effects of glutamine or alanyl glutamine parenteral supplementation on the liver oxidant/antioxidant balance and on cytochrome-P450-mediated detoxication in rats. Animals were infused for 5 d with standard total parenteral nutrition (TPN), glutamine-enriched TPN, or alanyl glutamine-enriched TPN. The hepatic concentration of glutathione was reduced, and the levels of thiobarbituric-acid-reactive substances (TBARS) were increased in animals receiving standard TPN. Both glutamine and alanyl glutamine supplementation normalized glutathione, but thiobarbituric-acid-reactive substance concentration was only decreased by ananyl glutamine. This effect was parallel to a partial recovery of the activity of antioxidant enzymes. Cytochrome-P450 liver content, cytochrome-P450-dependent monooxygenases, and antipyrine clearance were not modified by glutamine or alanyl glutamine. Our data suggest a better protection against free radicals by alanyl glutamine supplementation and an absence of effects of both glutamine and alanyl glutamine on liver oxidative metabolism.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0899-9007 ; PMID: 10696636 Version:1

Đang tìm Cơ sở dữ liệu bên ngoài...