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Functional and Biochemical Characterization of Hepatitis C Virus (HCV) Particles Produced in a Humanized Liver Mouse Model

Calattini, S ; Fusil, F ; Mancip, J ; Dao Thi, V. L ; Granier, C ; Gadot, N ; Scoazec, J.-Y ; Zeisel, Mirjam ; Baumert, Thomas F ; Lavillette, Dimitri ; Dreux, M ; Cosset, F.-L; Lyon 1, Depot 1 (Editor)

Journal of Biological Chemistry, 2015, Vol.290(38), pp.23173-23187 [Tạp chí có phản biện]

ISSN: 0021-9258 ; E-ISSN: 1083-351X ; DOI: 10.1074/jbc.M115.662999

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  • Nhan đề:
    Functional and Biochemical Characterization of Hepatitis C Virus (HCV) Particles Produced in a Humanized Liver Mouse Model
  • Tác giả: Calattini, S ; Fusil, F ; Mancip, J ; Dao Thi, V. L ; Granier, C ; Gadot, N ; Scoazec, J.-Y ; Zeisel, Mirjam ; Baumert, Thomas F ; Lavillette, Dimitri ; Dreux, M ; Cosset, F.-L
  • Lyon 1, Depot 1 (Editor)
  • Chủ đề: Life Sciences ; Human Health and Pathology ; Chemistry ; Anatomy & Physiology
  • Là 1 phần của: Journal of Biological Chemistry, 2015, Vol.290(38), pp.23173-23187
  • Mô tả: Lipoprotein components are crucial factors for hepatitis C virus (HCV) assembly and entry. As hepatoma cells producing cell culture-derived HCV (HCVcc) particles are impaired in some aspects of lipoprotein metabolism, it is of upmost interest to biochemically and functionally characterize the in vivo produced viral particles, particularly regarding how lipoprotein components modulate HCV entry by lipid transfer receptors such as scavenger receptor BI (SR-BI). Sera from HCVcc-infected liver humanized FRG mice were separated by density gradients. Viral subpopulations, termed HCVfrg particles, were characterized for their physical properties, apolipoprotein association, and infectivity. We demonstrate that, in contrast to the widely spread distribution of apolipoproteins across the different HCVcc subpopulations, the most infectious HCVfrg particles are highly enriched in apoE, suggesting that such apolipoprotein enrichment plays a role for entry of in vivo derived infectious...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0021-9258 ; E-ISSN: 1083-351X ; DOI: 10.1074/jbc.M115.662999

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