skip to main content
Ngôn ngữ:
Giới hạn tìm kiếm: Giới hạn tìm kiếm: Dạng tài nguyên Hiển thị kết quả với: Hiển thị kết quả với: Chỉ mục

Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia.(texto en ingles)(Resumen de autor)

Gracia, Rossana Villegas ; Alzate, Catalina Franco ; Henao, Javier Rendon ; Hernandez, Jose Domingo Torres ; Arbelaez, Patricia Elena Jaramillo

Colombia Medica, 2016, Vol.47(2) [Tạp chí có phản biện]

ISSN: 1657-9534

Toàn văn sẵn có

Trích dẫn Trích dẫn bởi
  • Nhan đề:
    Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia.(texto en ingles)(Resumen de autor)
  • Tác giả: Gracia, Rossana Villegas ; Alzate, Catalina Franco ; Henao, Javier Rendon ; Hernandez, Jose Domingo Torres ; Arbelaez, Patricia Elena Jaramillo
  • Chủ đề: Original Article ; Monoclonal B-Cell Lymphocytosis ; Chronic Lymphocytic Leukemia ; B Cells ; Flow Cytometry
  • Là 1 phần của: Colombia Medica, 2016, Vol.47(2)
  • Mô tả: Introduction: monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x109/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital series have manifested a higher risk in subjects with monoclonal B-cell lymphocytosis to progress to a chronic lymphocytic leukemia. The behavior of this hematologic entity is unknown therefore its frequency in sporadic chronic lymphocytic leukemia patient relatives was determined. Methods: transversal descriptive study, 8 color flow cytometry was performed using two of the tubes of the Euro Flow recommended panel, with modifications, for the diagnose of chronic lymphoproliferative disorders of B lymphocytes; besides, a fluorescence in situ hybridization was performed. univariate and bivariate analyses of the information were performed. Results: monoclonal B-cell lymphocytosis frequency found in 51 analyzed relatives was 2%, it was a female participant, 59 years old, with a total leukocyte count of 7.7x109/L and a B lymphocyte count of 0.124x109/L; from these, 0.04x109/L were clonal cells with restrictions of the kappa light chain. Rearrangements of the IGH gene (14q32) were found. Conclusion: monoclonal B-cell lymphocytosis was detected in one relative of a patient with sporadic chronic lymphocytic leukemia in a frequency similar to the one reported in general population.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 1657-9534

Đang tìm Cơ sở dữ liệu bên ngoài...