skip to main content
Ngôn ngữ:
Giới hạn tìm kiếm: Giới hạn tìm kiếm: Dạng tài nguyên Hiển thị kết quả với: Hiển thị kết quả với: Chỉ mục

Neisseria meningitidis NaIP cleaves human complement C3, facilitating degradation of C3b and survival in human serum.(MICROBIOLOGY)(Report)(Author abstract)

Del Tordello, Elena ; Vacca, Irene ; Ram, Sanjay ; Rappuoli, Rino ; Serruto, Davide

Proceedings of the National Academy of Sciences of the United States, Jan 7, 2014, Vol.111(1), p.427(6) [Tạp chí có phản biện]

ISSN: 0027-8424

Toàn văn sẵn có

Trích dẫn Trích dẫn bởi
  • Nhan đề:
    Neisseria meningitidis NaIP cleaves human complement C3, facilitating degradation of C3b and survival in human serum.(MICROBIOLOGY)(Report)(Author abstract)
  • Tác giả: Del Tordello, Elena ; Vacca, Irene ; Ram, Sanjay ; Rappuoli, Rino ; Serruto, Davide
  • Chủ đề: Neisseria Meningitidis -- Physiological Aspects ; Neisseria Meningitidis -- Health Aspects ; Host-parasite Relationships -- Research ; Immune Response -- Research ; Binding Sites (Biochemistry) -- Research ; Immunologic Research
  • Là 1 phần của: Proceedings of the National Academy of Sciences of the United States, Jan 7, 2014, Vol.111(1), p.427(6)
  • Mô tả: The complement system is a crucial component of the innate immune response against invading bacterial pathogens. The human pathogen Neisseria meningitidis (Nm) is known to possess several mechanisms to evade the complement system, including binding to complement inhibitors. In this study, we describe an additional mechanism used by Nm to evade the complement system and survive in human blood. Using an isogenic NaIP deletion mutant and NaIP complementing strains, we show that the autotransporter protease NaIP cleaves C3, the central component of the complement cascade. The cleavage occurs 4 aa upstream from the natural C3 cleavage site and produces shorter C3a-like and longer C3b-like fragments. The C3b-like fragment is degraded in the presence of the complement regulators (factors H and I), and this degradation results in lower deposition of C3b on the bacterial surface. We conclude that NaIP is an important factor to increase the survival of Nm in human serum. serum resistance | immune evasion www.pnas.org/cgi/doi/10.1073/pnas.1321556111
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0027-8424

Đang tìm Cơ sở dữ liệu bên ngoài...