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Zwitterionic hydrogels implanted in mice resist the foreign-body reaction.(LETTERS)(Report)

Zhang, Lei ; Cao, Zhiqiang ; Bai, Tao ; Carr, Louisa ; Ella-Menye, Jean-Rene ; Irvin, Colleen ; Ratner, Buddy D. ; Jiang, Shaoyi

Nature Biotechnology, 2013, Vol.31(6), p.553(5) [Tạp chí có phản biện]

ISSN: 1087-0156 ; DOI: 10.1038/nbt.2580

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  • Nhan đề:
    Zwitterionic hydrogels implanted in mice resist the foreign-body reaction.(LETTERS)(Report)
  • Tác giả: Zhang, Lei ; Cao, Zhiqiang ; Bai, Tao ; Carr, Louisa ; Ella-Menye, Jean-Rene ; Irvin, Colleen ; Ratner, Buddy D. ; Jiang, Shaoyi
  • Chủ đề: Prostheses and Implants – Innovations ; Zwitterions – Health Aspects ; Graft Rejection – Research
  • Là 1 phần của: Nature Biotechnology, 2013, Vol.31(6), p.553(5)
  • Mô tả: The performance of implantable biomedical devices is impeded by the foreign-body reaction, which results in formation of a dense collagenous capsule that blocks mass transport and/or electric communication between the implant and the body. No known materials or coatings can completely prevent capsule formation. Here we demonstrate that ultra-low-fouling zwitterionic hydrogels can resist the formation of a capsule for at least 3 months after subcutaneous implantation in mice. Zwitterionic hydrogels also promote angiogenesis in surrounding tissue, perhaps owing to the presence of macrophages exhibiting phenotypes associated with anti-inflammatory, pro-healing functions. Thus, zwitterionic hydrogels may be useful in a broad range of applications, including generation of biocompatible implantable medical devices and tissue scaffolds. [PUBLICATION ]
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 1087-0156 ; DOI: 10.1038/nbt.2580

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