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Structural basis of transcription initiation.(REPORTS)(Report)(Author abstract)

Zhang, Yu ; Feng, Yu ; Chatterjee, Sujoy ; Tuske, Steve ; Ho, Mary X. ; Arnold, Eddy ; Ebright, Richard H.

Science, Nov 23, 2012, Vol.338(6110), p.1076(5) [Tạp chí có phản biện]

ISSN: 0036-8075

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  • Nhan đề:
    Structural basis of transcription initiation.(REPORTS)(Report)(Author abstract)
  • Tác giả: Zhang, Yu ; Feng, Yu ; Chatterjee, Sujoy ; Tuske, Steve ; Ho, Mary X. ; Arnold, Eddy ; Ebright, Richard H.
  • Chủ đề: Transcription (Genetics) -- Research ; Rna Polymerases -- Physiological Aspects ; Rna Polymerases -- Health Aspects ; Promoters (Genetics) -- Physiological Aspects ; Promoters (Genetics) -- Health Aspects
  • Là 1 phần của: Science, Nov 23, 2012, Vol.338(6110), p.1076(5)
  • Mô tả: During transcription initiation, RNA polymerase (RNAP) binds and unwinds promoter DNA to form an RNAP-promoter open complex. We have determined crystal structures at 2.9 and 3.0 [Angstrom] resolution of functional transcription initiation complexes comprising Thermus thermophilus RNA polymerase, [[sigma].sup.A], and a promoter DNA fragment corresponding to the transcription bubble and downstream double-stranded DNA of the RNAP-promoter open complex. The structures show that c recognizes the -10 element and discriminator element through interactions that include the unstacking and insertion into pockets of three DNA bases and that RNAP recognizes the -4/+2 region through interactions that include the unstacking and insertion into a pocket of the +2 base. The structures further show that interactions between o and template-strand single-stranded DNA (ssDNA) preorganize template-strand ssDNA to engage the RNAP active center. 10.1126/science.1227786
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0036-8075

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