skip to main content
Ngôn ngữ:
Giới hạn tìm kiếm: Giới hạn tìm kiếm: Dạng tài nguyên Hiển thị kết quả với: Hiển thị kết quả với: Chỉ mục

A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia.(RESEARCH ARTICLE)(Report)(Author abstract)

Button, Brian ; Cai, Li - Heng ; Ehre, Camille ; Kesimer, Mehmet ; Hill, David B. ; Sheehan, John K. ; Boucher, Richard C. ; Rubinstein, Michael

Science, August 24, 2012, Vol.337(6097), p.937(5) [Tạp chí có phản biện]

ISSN: 0036-8075

Toàn văn sẵn có

Trích dẫn Trích dẫn bởi
  • Nhan đề:
    A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia.(RESEARCH ARTICLE)(Report)(Author abstract)
  • Tác giả: Button, Brian ; Cai, Li - Heng ; Ehre, Camille ; Kesimer, Mehmet ; Hill, David B. ; Sheehan, John K. ; Boucher, Richard C. ; Rubinstein, Michael
  • Chủ đề: Respiratory Mucosa -- Observations ; Mucociliary System -- Research
  • Là 1 phần của: Science, August 24, 2012, Vol.337(6097), p.937(5)
  • Mô tả: Mucus clearance is the primary defense mechanism that protects airways from inhaled infectious and toxic agents. In the current gel-on-liquid mucus clearance model, a mucus get is propelled on top of a "watery" periciliary layer surrounding the cilia. However, this model fails to explain the formation of a distinct mucus layer in health or why mucus clearance fails in disease. We propose a get-on-brush model in which the pericitiary layer is occupied by membrane-spanning mucins and mucopolysaccharides densely tethered to the airway surface. This brush prevents mucus penetration into the periciliary space and causes mucus to form a distinct layer. The relative osmotic moduli of the mucus and periciliary brush layers explain both the stability of mucus clearance in health and its failure in airway disease. 10.1126/science.1223012
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0036-8075

Đang tìm Cơ sở dữ liệu bên ngoài...