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Comparative Analysis of Esterase Activities of Human, Mouse, and Rat Blood.(Report)

Rudakova, E. V. ; Boltneva, N. P. ; Makhaeva, G. F.

Bulletin of Experimental Biology and Medicine, Oct, 2011, Vol.152(1), p.73(3) [Tạp chí có phản biện]

ISSN: 0007-4888

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  • Nhan đề:
    Comparative Analysis of Esterase Activities of Human, Mouse, and Rat Blood.(Report)
  • Tác giả: Rudakova, E. V. ; Boltneva, N. P. ; Makhaeva, G. F.
  • Chủ đề: Enzymology -- Comparative Analysis ; Hydrolases -- Comparative Analysis
  • Là 1 phần của: Bulletin of Experimental Biology and Medicine, Oct, 2011, Vol.152(1), p.73(3)
  • Mô tả: Byline: E. V. Rudakova (1), N. P. Boltneva (1), G. F. Makhaeva (1) Keywords: acetylcholinesterase; butyrylcholinesterase; carboxylesterase; paraoxonase; blood Abstract: Acetylcholinesterase, butyrylcholinesterase, carboxylesterase, and paraoxonase activities in human, mouse, and rat blood were measured. The proportions of these enzymes activities differed significantly. In humans, the most significant were cholinesterase activities, while in rats and mice the contribution of carboxylesterase activity was the greatest. High arylesterase activity of paraoxonase was observed in all cases. Species-specific differences should be taken into consideration when carrying out preclinical trials on rodents for optimization of the pharmacokinetic characteristics of drugs containing complex ester groups. Author Affiliation: (1) Laboratory of Molecular Toxicology, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia Article History: Registration Date: 08/11/2011 Received Date: 27/05/2010 Online Date: 17/11/2011 Article note: Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 152, No. 7, pp. 80--82, July, 2011
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0007-4888

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