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Role Sympathetic Autonomic Nervous System in the Regulation of Immune Response during Myasthenia.(Report)

Lantsova, V. B. ; Sepp, E. K. ; Kozlovsky, A. S.

Bulletin of Experimental Biology and Medicine, July, 2011, Vol.151(3), p.353(3) [Tạp chí có phản biện]

ISSN: 0007-4888

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  • Nhan đề:
    Role Sympathetic Autonomic Nervous System in the Regulation of Immune Response during Myasthenia.(Report)
  • Tác giả: Lantsova, V. B. ; Sepp, E. K. ; Kozlovsky, A. S.
  • Chủ đề: Enzymes -- Physiological Aspects ; Enzymology -- Physiological Aspects
  • Là 1 phần của: Bulletin of Experimental Biology and Medicine, July, 2011, Vol.151(3), p.353(3)
  • Mô tả: Byline: V. B. Lantsova (1,2), E. K. Sepp (1,2), A. S. Kozlovsky (1,2) Keywords: myasthenia; [beta].sub.2-adrenoreceptor; enzyme immune assay; salbutamol Abstract: In 12 patients with myasthenia, the content of [beta].sub.2-adrenoreceptors on the cell surface and activity of intracellular lymphocytic enzymes were determined by EIA and biochemical methods, respectively. In comparison with the normal, these patients demonstrated pronounced elevation in the content of [beta].sub.2-adrenoreceptors and significant changes in activity of lymphocytic enzymes. In 10 of 12 patients, administration of the agonists to [beta].sub.2-adrenoreceptors resulted in health improvement accompanied by normalization of EMG and immunobiochemical indices. Our findings suggest that intra- and intercellular signaling pathways and their modification can serve as potential targets for the therapy. Author Affiliation: (1) State Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow, Russia (2) Children's Clinical Hospital, Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia Article History: Registration Date: 06/07/2011 Received Date: 25/02/2010 Online Date: 12/07/2011 Article note: Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 151, No. 03, pp. 328--330, March 2011
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0007-4888

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