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Crystal structure of human adenovirus at 3.5 [Angstrom] resolution.(REPORTS)(Author abstract)(Report)

Reddy, Vijay S. ; Natchiar, S. Kundhavai ; Stewart, Phoebe L. ; Nemerow, Glen R.

Science, August 27, 2010, Vol.329(5995), p.1071(5) [Tạp chí có phản biện]

ISSN: 0036-8075

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  • Nhan đề:
    Crystal structure of human adenovirus at 3.5 [Angstrom] resolution.(REPORTS)(Author abstract)(Report)
  • Tác giả: Reddy, Vijay S. ; Natchiar, S. Kundhavai ; Stewart, Phoebe L. ; Nemerow, Glen R.
  • Chủ đề: Human Adenoviruses -- Research
  • Là 1 phần của: Science, August 27, 2010, Vol.329(5995), p.1071(5)
  • Mô tả: Rational development of adenoyirus vectors for therapeutic gene transfer is hampered by the lack of accurate structural information. Here, we report the x-ray structure at 3.5 angstrom resolution of the 150-megadalton adenovirus capsid containing nearly 1 million amino acids. We describe interactions between the major capsid protein (hexon) and several accessory molecules that stabilize the capsid. The virus structure also reveals an altered association between the penton base and the trimeric fiber protein, perhaps reflecting an early event in cell entry. The high-resolution structure provides a substantial advance toward understanding the assembly and cell entry mechanisms of a large double-stranded DNA virus and provides new opportunities for improving adenovirus-mediated gene transfer. 10.1126/science.1187292
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0036-8075

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