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Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine.(MEDICAL SCIENCES)(Author abstract)(Report)

Galli, Grazia ; Hancock, Kathy ; Hoschler, Katja ; Devos, Joshua ; Praus, Michaela ; Bardelli, Monia ; Malzone, Carmine ; Castellino, Flora ; Gentile, Chiara ; Mcnally, Teresa ; Del Giudice, Giuseppe ; Banzhoff, Angelika ; Brauer, Volker ; Montomoli, Emanuele ; Zambon, Maria ; Katz, Jacqueline ; Nicholson, Karl ; Stephenson, Iain

Proceedings of the National Academy of Sciences of the United States, May 12, 2009, Vol.106(19), p.7962(6) [Tạp chí có phản biện]

ISSN: 0027-8424

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  • Nhan đề:
    Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine.(MEDICAL SCIENCES)(Author abstract)(Report)
  • Tác giả: Galli, Grazia ; Hancock, Kathy ; Hoschler, Katja ; Devos, Joshua ; Praus, Michaela ; Bardelli, Monia ; Malzone, Carmine ; Castellino, Flora ; Gentile, Chiara ; Mcnally, Teresa ; Del Giudice, Giuseppe ; Banzhoff, Angelika ; Brauer, Volker ; Montomoli, Emanuele ; Zambon, Maria ; Katz, Jacqueline ; Nicholson, Karl ; Stephenson, Iain
  • Chủ đề: B Cells -- Health Aspects ; Immunity (Physiology) -- Research ; Influenza -- Prevention ; Antibodies -- Properties
  • Là 1 phần của: Proceedings of the National Academy of Sciences of the United States, May 12, 2009, Vol.106(19), p.7962(6)
  • Mô tả: Proactive priming before the next pandemic could induce immune memory responses to novel influenza antigens. In an open-label study, we analyzed B cell memory and antibody responses of 54 adults who received 2 7.5-[micro]g doses of MF59-adjuvanted A/Vietnam/ 1194/2004 clade 1 (H5N1) vaccine. Twenty-four subjects had been previously primed with MF59-adjuvanted or plain clade 0-like A/duck/Singapore/1997 (H5N3) vaccine during 1999-2001. The prevaccination frequency of circulating memory B cells reactive to A/Vietnam/1194/2004 was low in both primed and unprimed individuals. However, at day 21 after boosting, MF59-adjuvanted primed subjects displayed a higher frequency of H5N1-specific memory B cells than plain-primed or unprimed subjects. The immune memory was rapidly mobilized by a single vaccine administration and resulted in high titers of neutralizing antibodies to antigenically diverse clade 0, 1, and 2 H5N1 viruses already at day 7. In general, postvaccination antibody titers were significantly higher in primed subjects than in unprimed subjects. Subjects primed with MF59-adjuvanted vaccine responded significantly better than those primed with plain vaccine, most notably in early induction and duration of cross-reacting antibody responses. After 6 months, high titers of cross-reactive antibody remained detectable among MF59-primed subjects. We conclude that distant priming with clade 0-like H5N3 induces a pool of cross-reactive memory B cells that can be boosted rapidly years afterward by a mismatched MF59-adjuvanted vaccine to generate high titers of cross-reactive neutralizing antibodies rapidly. These results suggest that pre-pandemic vaccination strategies should be considered.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0027-8424

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