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Group B Streptococcus crosses human epithelial cells by a paracellular route

Soriani, Marco ; Santi, Isabella ; Taddei, Annarita ; Rappuoli, Rino ; Grandi, Guido ; Telford, John L.

Journal of Infectious Diseases, Jan 15, 2006, Vol.193(2), p.241(10) [Tạp chí có phản biện]

ISSN: 0022-1899

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  • Nhan đề:
    Group B Streptococcus crosses human epithelial cells by a paracellular route
  • Tác giả: Soriani, Marco ; Santi, Isabella ; Taddei, Annarita ; Rappuoli, Rino ; Grandi, Guido ; Telford, John L.
  • Chủ đề: Colonization -- Methods ; Streptococcus Agalactiae -- Risk Factors
  • Là 1 phần của: Journal of Infectious Diseases, Jan 15, 2006, Vol.193(2), p.241(10)
  • Mô tả:

    Colonization of the colon and vagina is thought to be important in the pathogenesis of group B Streptococcus (GBS) infection. However, little is known about the strategies used by GBS to translocate through the epithelial barrier during the onset of disease. We used differentiated epithelial cells grown on transwell inserts as a model of the epithelial barrier. Bacterial translocation occurred without a detectable decrease in transepithelial resistance. Whereas acapsular GBS was better able to adhere to and invade epithelial cells, the percentage of bacteria translocating across the epithelial monolayer was independent of the presence of the capsule. Transmission electron microscopy showed the intimate association of GBS with intercellular junctions and the capacity to cross the monolayer by a paracellular mechanism. This process consisted of an active and transient opening of cell junctions. Indeed, GBS was preferentially found along the cell perimeter, where it colocalized with junctional protein complexes.


  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0022-1899

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