skip to main content
Ngôn ngữ:
Giới hạn tìm kiếm: Giới hạn tìm kiếm: Dạng tài nguyên Hiển thị kết quả với: Hiển thị kết quả với: Chỉ mục

Four Jointed Box 1 Promotes Angiogenesis and Is Associated with Poor Patient Survival in Colorectal Carcinoma.(Research Article)

Al - Greene, Nicole T. ; Means, Anna L. ; Lu, Pengcheng ; Jiang, Aixiang ; Schmidt, Carl R. ; Chakravarthy, A. Bapsi ; Merchant, Nipun B. ; Washington, M. Kay ; Zhang, Bing ; Shyr, Yu ; Deane, Natasha G. ; Beauchamp, R. Daniel

PLoS ONE, July 29, 2013, Vol.8(7), p.e69660 [Tạp chí có phản biện]

ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0069660

Toàn văn sẵn có

Trích dẫn Trích dẫn bởi
  • Nhan đề:
    Four Jointed Box 1 Promotes Angiogenesis and Is Associated with Poor Patient Survival in Colorectal Carcinoma.(Research Article)
  • Tác giả: Al - Greene, Nicole T. ; Means, Anna L. ; Lu, Pengcheng ; Jiang, Aixiang ; Schmidt, Carl R. ; Chakravarthy, A. Bapsi ; Merchant, Nipun B. ; Washington, M. Kay ; Zhang, Bing ; Shyr, Yu ; Deane, Natasha G. ; Beauchamp, R. Daniel
  • Chủ đề: Colon Cancer -- Prognosis ; Colon Cancer -- Patient Outcomes ; Messenger Rna ; Sulfates ; Dextrans ; Genes
  • Là 1 phần của: PLoS ONE, July 29, 2013, Vol.8(7), p.e69660
  • Mô tả: Angiogenesis, the recruitment and re-configuration of pre-existing vasculature, is essential for tumor growth and metastasis. Increased tumor vascularization often correlates with poor patient outcomes in a broad spectrum of carcinomas. We identified four jointed box 1 (FJX1) as a candidate regulator of tumor angiogenesis in colorectal cancer. FJX1 mRNA and protein are upregulated in human colorectal tumor epithelium as compared with normal epithelium and colorectal adenomas, and high expression of FJX1 is associated with poor patient prognosis. FJX1 mRNA expression in colorectal cancer tissues is significantly correlated with changes in known angiogenesis genes. Augmented expression of FJX1 in colon cancer cells promotes growth of xenografts in athymic mice and is associated with increased tumor cell proliferation and vascularization. Furthermore, FJX1 null mice develop significantly fewer colonic polyps than wild-type littermates after combined dextran sodium sulfate (DSS) and azoxymethane (AOM) treatment. In vitro, conditioned media from FJX1 expressing cells promoted endothelial cell capillary tube formation in a HIF1-[alpha] dependent manner. Taken together our results support the conclusion that FJX1 is a novel regulator of tumor progression, due in part, to its effect on tumor vascularization.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0069660

Đang tìm Cơ sở dữ liệu bên ngoài...