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Innate and specific gut-associated immunity and microbial interference.(Report)

Singh, Vinod ; Singh, Kiran ; Amdekar, Sarika ; Singh, Desh Deepak ; Tripathi, Parul ; Sharma, Ganda L. ; Yadav, Hariom

FEMS Immunology and Medical Microbiology, Jan, 2009, Vol.55(1), p.6(7) [Tạp chí có phản biện]

ISSN: 0928-8244

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  • Nhan đề:
    Innate and specific gut-associated immunity and microbial interference.(Report)
  • Tác giả: Singh, Vinod ; Singh, Kiran ; Amdekar, Sarika ; Singh, Desh Deepak ; Tripathi, Parul ; Sharma, Ganda L. ; Yadav, Hariom
  • Chủ đề: Peptides ; Enzymology ; Antigens ; Proteases ; Casein ; Bookbinding
  • Là 1 phần của: FEMS Immunology and Medical Microbiology, Jan, 2009, Vol.55(1), p.6(7)
  • Mô tả: To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1574-695X.2008.00497.x Byline: Vinod Singh (1), Kiran Singh (1), Sarika Amdekar (1), Desh Deepak Singh (2), Parul Tripathi (3), Ganda L. Sharma (4), Hariom Yadav (5) Keywords: anti-inflammatory; cytokines; gut-associated immunity; microbial interference; probiotics; replacement therapy Abstract: Abstract Certain bacterial species isolated from the gastrointestinal microbial communities release low-molecular-weight peptides into milk products using bacteria-derived proteases that degrade milk casein, and thereby generate peptides, triggering immune responses. The intestinal microbial communities contributes to the processing of food antigens in the gut. The present study was designed to investigate the immunomodulatory effects of microbial interference to determine whether casein degraded by probiotic bacteria-derived enzymes could modulate the cytokine production and peripheral blood mononuclear cells in atopic infants with cow or other synthetic milk allergy. Without hydrolyzation, casein reduced the production of interleukin-4, which indicates that probiotics modify the structure of potentially harmful antigens and thereby alter the mode of their immunogenicity. Intraluminal bacterial antigens have been reported to elicit specific responses in the gut-associated lymphoid tissue (GALT) through the binding capacity of intraluminal bacterial antigens to epithelial cells, which allows antigen entry via enterocytes and aids in evading the tolerance function in Peyer's patches. Such tonic immune responses in the GALT may allow control of the metabolic activity and balance of the gut microbial communities. Author Affiliation: (1)Department of Microbiology, Barkatullah University, Bhopal, MP, India (2)Institute of Biomedical Sciences, Bundelkhand University, Jhansi, India (3)Basic Immunology Laboratory, International Center for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India (4)Department of Biochemistry, Institute of Genomics and Integrative Biology, New Delhi, India (5)National Institute for Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA Article History: Received 15 May 2008; revised 8 September 2008; accepted 13 October 2008.First published online 11 December 2008. Article note: Correspondence: Vinod Singh, Department of Microbiology, Barkatullah University, Bhopal, MP 462026, India. Tel.: +91 0755 6458209; fax: +91 0755 2677729; e-mail: vsingh3@rediffmail.com
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0928-8244

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