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The role of Notch signalling and numb function in mechanosensory organ formation in the spider Cupiennius salei

Gold, Katrina ; Cotton, James A ; Stollewerk, Angelika

Developmental Biology, 01 March 2009, Vol.327(1), pp.121-131 [Tạp chí có phản biện]

ISSN: 0012-1606 ; E-ISSN: 1095-564X ; DOI: 10.1016/j.ydbio.2008.12.004

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  • Nhan đề:
    The role of Notch signalling and numb function in mechanosensory organ formation in the spider Cupiennius salei
  • Tác giả: Gold, Katrina ; Cotton, James A ; Stollewerk, Angelika
  • Chủ đề: Peripheral Neurogenesis ; Mechanosensory Organs ; Notch Signalling ; Numb ; Prospero ; Delta ; Cell Fate ; Chelicerate ; Cupiennius Salei ; Biology ; Zoology
  • Là 1 phần của: Developmental Biology, 01 March 2009, Vol.327(1), pp.121-131
  • Mô tả: In the spider the mechanosensory organs of the legs are generated from epithelial sensory precursor groups which are specified by elevated levels of the homologues and . Neural precursors delaminate from the groups and occupy positions basal and proximal to the accessory cells which remain in the epithelium. Here we analyse the role of Notch signalling and function in the development of the mechanosensory organs of the spider. We show that Notch signalling is required for several processes: the selection of the sensory precursor groups, the maintenance of undifferentiated sensory precursors, the binary cell fate decision between accessory and neural fate and the differentiation of sensory neurons. Our data suggest that Numb antagonises Notch signalling in the neural precursors, which results in activation of the neural cell fate determinant Prospero and delamination of the neural precursors from the epithelium. is expressed de novo in sensory neural precursors and we assume that the expression of the gene is regulated by the Notch to Numb ratio within the sensory precursors. Interestingly, the spider RNAi phenotype resembles the loss of function phenotypes in the mammalian nervous system, indicating that the interaction between Notch signalling and Numb might play a similar role in both systems.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0012-1606 ; E-ISSN: 1095-564X ; DOI: 10.1016/j.ydbio.2008.12.004

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