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Low maternal melatonin level increases autism spectrum disorder risk in children

Braam, Wiebe ; Ehrhart, Friederike ; Maas, Anneke P.H.M ; Smits, Marcel G ; Curfs, Leopold

Research in Developmental Disabilities, November 2018, Vol.82, pp.79-89 [Tạp chí có phản biện]

ISSN: 0891-4222 ; E-ISSN: 1873-3379 ; DOI: 10.1016/j.ridd.2018.02.017

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  • Nhan đề:
    Low maternal melatonin level increases autism spectrum disorder risk in children
  • Tác giả: Braam, Wiebe ; Ehrhart, Friederike ; Maas, Anneke P.H.M ; Smits, Marcel G ; Curfs, Leopold
  • Chủ đề: Autism Spectrum Disorder ; Genetics ; Melatonin ; Intellectual Disability ; 6-Sulfatoxymelatonin ; Social Welfare & Social Work
  • Là 1 phần của: Research in Developmental Disabilities, November 2018, Vol.82, pp.79-89
  • Mô tả: It is assumed that autism spectrum disorder (ASD) is caused by a combination of inherited variation and common variation as well as environmental factors. It often co-occurs with intellectual disability (ID). Almost eight hundred potential causative genetic variations have been found in ASD patients. However, not one of them is responsible for more than 1% of ASD cases. Low melatonin levels are a frequent finding in ASD patients. Melatonin levels are negatively correlated with severity of autistic impairments, it is important for normal neurodevelopment and is highly effective in protecting DNA from oxidative damage. Melatonin deficiency could be a major factor, and well a common heritable variation, that increases the susceptibility to environmental risk factors for ASD. ASD is already present at birth. As the fetus does not produce melatonin, low maternal melatonin levels may be involved. We measured 6-sulfatoxymelatonin in urine of 60...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0891-4222 ; E-ISSN: 1873-3379 ; DOI: 10.1016/j.ridd.2018.02.017

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