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Urine 6-sulfatoxymelatonin levels are inversely associated with arterial stiffness in post-menopausal women

Lee, Jee-Yon ; Lee, Duk-Chul

Maturitas, June 2014, Vol.78(2), pp.117-122 [Tạp chí có phản biện]

ISSN: 0378-5122 ; E-ISSN: 1873-4111 ; DOI: 10.1016/j.maturitas.2014.03.010

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  • Nhan đề:
    Urine 6-sulfatoxymelatonin levels are inversely associated with arterial stiffness in post-menopausal women
  • Tác giả: Lee, Jee-Yon ; Lee, Duk-Chul
  • Chủ đề: Melatonin ; 6-Sulfatoxymelatonin ; Arterial Stiffness ; Atherosclerosis ; Menopause ; Medicine
  • Là 1 phần của: Maturitas, June 2014, Vol.78(2), pp.117-122
  • Mô tả: The secretion of melatonin, a pleiotropic hormone mainly synthesized by the pineal gland, typically decreases with age and may be associated with the development of aging-related pathologic conditions such as cardiovascular disease. Atherosclerosis is an aging-related disease, the pathogenesis of which involves chronic inflammation and increased oxidative stress. Since melatonin has both anti-oxidant and anti-inflammatory properties, it may be associated with atherosclerosis. Therefore, we investigated the relationship between urine concentrations of 6-sulfatoxymelatonin (aMT6s) and arterial stiffness in post-menopausal women. A total of 66 post-menopausal women participated in the study. Melatonin secretion was estimated by measuring aMT6s levels in first morning urine samples. The cardio-ankle vascular index (CAVI) was used as an indicator of arterial stiffness. Estimated mean CAVI decreased gradually with increasing aMT6s quartiles. The...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0378-5122 ; E-ISSN: 1873-4111 ; DOI: 10.1016/j.maturitas.2014.03.010

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