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106. Deep repetitive transcranial magnetic stimulation (rTMS) with H-coil coupled with cycling in chronic lower limb dysfuncion after stroke: A randomized, placebo-controlled, crossover study

Chieffo, R ; Giatsidis, F ; Houdayer, E ; Fichera, M ; Nuara, A ; Coppi, E ; Ferrari, L ; Di Maggio, G ; Santangelo, R ; Poggi, A ; Sessa, M ; Comola, M ; Zangen, A ; Comi, G ; Leocani, L

Clinical Neurophysiology, January 2015, Vol.126(1), pp.e24-e25 [Tạp chí có phản biện]

ISSN: 1388-2457 ; E-ISSN: 1872-8952 ; DOI: 10.1016/j.clinph.2014.10.125

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  • Nhan đề:
    106. Deep repetitive transcranial magnetic stimulation (rTMS) with H-coil coupled with cycling in chronic lower limb dysfuncion after stroke: A randomized, placebo-controlled, crossover study
  • Tác giả: Chieffo, R ; Giatsidis, F ; Houdayer, E ; Fichera, M ; Nuara, A ; Coppi, E ; Ferrari, L ; Di Maggio, G ; Santangelo, R ; Poggi, A ; Sessa, M ; Comola, M ; Zangen, A ; Comi, G ; Leocani, L
  • Chủ đề: Medicine
  • Là 1 phần của: Clinical Neurophysiology, January 2015, Vol.126(1), pp.e24-e25
  • Mô tả: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.clinph.2014.10.125 Byline: R. Chieffo, F. Giatsidis, E. Houdayer, M. Fichera, A. Nuara, E. Coppi, L. Ferrari, G. Di Maggio, R. Santangelo, A. Poggi, M. Sessa, M. Comola, A. Zangen, G. Comi, L. Leocani Abstract: Repetitive transcranial magnetic stimulation (rTMS) has been recognized as a promising intervention for treatment of post-stroke deficits. We evaluated the feasibility, safety and efficacy of excitatory Hz rTMS with H-coil over the leg motor areas combined with active cycling on paretic lower limb motor function in chronic post-stroke. rTMS was delivered with the H-coil targeting the lower limbs (real or sham for 11 sessions over 3weeks, with cross-over after 4weeks wash-out, in 12 subjects with first stroke more than 6months before. Lower limb function was assessed with the Fugl-Meyer lower limb scale (FM-LL), with additional timed measures (10-m and 6min walking tests) and modified ashworth scale to the lower limb. No participant reported adverse effects. Real rTMS treatment was associated with a significant improvement in FM-LL scores (p <0.005) with 66% vs 9% responders (p =0.007 chi square). The 10min test did not significantly improve and the 6min test improved after both treatments (p <0.01), without significant differences between them. These findings suggest that bilateral high frequency rTMS with H-coil targeting the lower limbs is safe and, associated with motor training, may have a beneficial role in motor recovery from chronic stroke.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 1388-2457 ; E-ISSN: 1872-8952 ; DOI: 10.1016/j.clinph.2014.10.125

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