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Effect of long-term therapy with ramipril in high-risk women

Lonn, Eva ; Roccaforte, Rosa ; Yi, Qilong ; Dagenais, Gilles ; Sleight, Peter ; Bosch, Jackie ; Suhan, Pamela ; Micks, Mary ; Probstfield, Jeffrey ; Bernstein, Victoria ; Yusuf, Salim

Journal of the American College of Cardiology, 21 August 2002, Vol.40(4), pp.693-702 [Tạp chí có phản biện]

ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/S0735-1097(02)02035-1

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  • Nhan đề:
    Effect of long-term therapy with ramipril in high-risk women
  • Tác giả: Lonn, Eva ; Roccaforte, Rosa ; Yi, Qilong ; Dagenais, Gilles ; Sleight, Peter ; Bosch, Jackie ; Suhan, Pamela ; Micks, Mary ; Probstfield, Jeffrey ; Bernstein, Victoria ; Yusuf, Salim
  • Chủ đề: Medicine
  • Là 1 phần của: Journal of the American College of Cardiology, 21 August 2002, Vol.40(4), pp.693-702
  • Mô tả: We evaluated the effects of long-term therapy with the angiotensin-converting enzyme (ACE) inhibitor ramipril on major cardiovascular (CV) outcomes in high-risk women. The effect of long-term ACE inhibitor therapy in high-risk women without heart failure and with preserved left ventricular (LV) systolic function has not been previously reported. The Heart Outcomes Prevention Evaluation (HOPE) trial is a large, randomized clinical trial that evaluated ramipril and vitamin E in high-risk patients. We present the preplanned analysis of the effects of ramipril in women in the HOPE study. The study randomized 2,480 women aged ≥55 years with vascular disease or diabetes and at least one additional CV risk factor and without heart failure or a known low LV ejection fraction to ramipril (10 mg/day) or placebo. The primary outcome was the composite of myocardial infarction, stroke or CV death. Average follow-up was 4.5 years. Treatment...
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0735-1097 ; E-ISSN: 1558-3597 ; DOI: 10.1016/S0735-1097(02)02035-1

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