skip to main content
Ngôn ngữ:
Giới hạn tìm kiếm: Giới hạn tìm kiếm: Dạng tài nguyên Hiển thị kết quả với: Hiển thị kết quả với: Chỉ mục

Role of the leukocyte-adhesion molecule L-selectin in experimental autoimmune encephalomyelitis

Archelos, Juan J ; Jung, Stefan ; Rinner, Walter ; Lassmann, Hans ; Miyasaka, Masayuki ; Hartung, Hans-Peter

Journal of the Neurological Sciences, 1998, Vol.159(2), pp.127-134 [Tạp chí có phản biện]

ISSN: 0022-510X ; E-ISSN: 1878-5883 ; DOI: 10.1016/S0022-510X(98)00154-3

Toàn văn sẵn có

Trích dẫn Trích dẫn bởi
  • Nhan đề:
    Role of the leukocyte-adhesion molecule L-selectin in experimental autoimmune encephalomyelitis
  • Tác giả: Archelos, Juan J ; Jung, Stefan ; Rinner, Walter ; Lassmann, Hans ; Miyasaka, Masayuki ; Hartung, Hans-Peter
  • Chủ đề: Eae ; Autoimmune Disease ; Adhesion Molecules ; CNS ; Therapy ; Medicine
  • Là 1 phần của: Journal of the Neurological Sciences, 1998, Vol.159(2), pp.127-134
  • Mô tả: L-selectin is an adhesion molecule expressed on T cells and monocytes. It mediates rolling - the initial step of transendothelial migration. In this study, we investigated the role of L-selectin in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. EAE was induced in Lewis rats by active sensitization with myelin basic protein (MBP-EAE), or by adoptive transfer using MBP specific T cells (AT-EAE). Treatment with HRL3, a monoclonal antibody to L-selectin, and its F(ab') sub(2) fragments efficiently suppressed MBP-EAE, and had a mild inhibitory effect on AT-EAE. Histological examination revealed a marked reduction of inflammatory infiltrates after treatment with HRL3. Administration of the control antibody HRL4 did not significantly alter the course of the disease. HRL3 caused T-cell depletion in the draining lymph nodes and spleen and a downregulation of L-selectin expression on T cells. We conclude that L-selectin-dependent mechanisms are involved in the pathogenesis of EAE. Modulation of L-selectin in vivo by antibodies or by competitive antagonists could be a novel therapeutic approach to autoimmune diseases of the central nervous system.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0022-510X ; E-ISSN: 1878-5883 ; DOI: 10.1016/S0022-510X(98)00154-3

Đang tìm Cơ sở dữ liệu bên ngoài...