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Defects in Pulmonary Vasculature and Perinatal Lung Hemorrhage in Mice Heterozygous Null for the Forkhead Box f1 Transcription Factor

Kalinichenko, Vladimir V ; Lim, Lorena ; Stolz, Donna Beer ; Shin, Brian ; Rausa, Francisco M ; Clark, Jean ; Whitsett, Jeffrey A ; Watkins, Simon C ; Costa, Robert H

Developmental Biology, 15 July 2001, Vol.235(2), pp.489-506 [Tạp chí có phản biện]

ISSN: 0012-1606 ; E-ISSN: 1095-564X ; DOI: 10.1006/dbio.2001.0322

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  • Nhan đề:
    Defects in Pulmonary Vasculature and Perinatal Lung Hemorrhage in Mice Heterozygous Null for the Forkhead Box f1 Transcription Factor
  • Tác giả: Kalinichenko, Vladimir V ; Lim, Lorena ; Stolz, Donna Beer ; Shin, Brian ; Rausa, Francisco M ; Clark, Jean ; Whitsett, Jeffrey A ; Watkins, Simon C ; Costa, Robert H
  • Chủ đề: Winged-Helix Transcription Factor ; Hfh-8 ; Freac-1 ; Foxf1 ; Alveolar Endothelial Cell ; Type I Epithelial Cell ; Bronchiolar Smooth Muscle Cells ; PECAM-1 ; Biology ; Zoology
  • Là 1 phần của: Developmental Biology, 15 July 2001, Vol.235(2), pp.489-506
  • Mô tả: Decreased pulmonary expression of Forkhead Box f1 (Foxf1) transcription factor was associated with lethal alveolar hemorrhage in 55% of the Foxf1 +/- newborn mice. The severity of the pulmonary abnormalities correlates with the levels of Foxf1 mRNA. Defects in alveolarization and vasculogenesis were observed in subsets of the Foxf1 +/- mice with relatively low levels of expression from the normal Foxf1 allele. Lung hemorrhage was coincident with disruption of the mesenchymal-epithelial cell interfaces in the alveolar and bronchiolar regions of the lung parenchyma and was associated with increased apoptosis and reduced surfactant protein B (SP-B) expression. Finally, the lung defect associated with the Foxf1 +/- mutation was accompanied by reduced expression of vascular endothelial growth factor (VEGF), the VEGF receptor 2 (Flk-1), bone morphogenetic protein 4 (Bmp-4), and the transcription factors of the Brachyury T-Box family (Tbx2-Tbx5) and Lung Kruppel-like Factor. Reduction in the level of Foxf1 caused neonatal pulmonary hemorrhage and abnormalities in alveologenesis, implicating this transcription factor in the regulation of mesenchyme-epithelial interaction critical for lung morphogenesis. Key Words: winged-helix transcription factor; HFH-8; Freac-1; Foxf1; alveolar endothelial cell; Type I epithelial cell; bronchiolar smooth muscle cells; PECAM-1.
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 0012-1606 ; E-ISSN: 1095-564X ; DOI: 10.1006/dbio.2001.0322

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